| 孙德全,蔡光华,朱宝根,符新建,顾旭杰,杨捷,葛学红.百白破应急接种效果观察[J].Chinese journal of Epidemiology,1990,11(6):345-347 |
| 百白破应急接种效果观察 |
| The Effect of the Emergent Vaccination Using DTP Vaccine to Control the Outbreak of Pertussis |
| Received:December 27, 1989 Revised:April 03, 1990 |
| DOI： |
| KeyWord: 百白破混合疫苗 百日咳 应急接种 |
| English Key Word: DTP vaccine Pertussis Emergent vaccination |
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| Abstract: |
| 观察了百白破混合疫苗和安慰剂应急接种控制百日咳爆发点疫情的血清学和现场流行病学效果。观察对象为有百日咳免疫史及接触史的4~6岁幼儿园儿童,随机分成两组,百白破接种76人,安慰剂接种72人。结果:接种后未见强反应及异常反应;百白破应急接种二周及三个月百日咳的GMT比接种前分别上升18.14、4.73倍;接种后21天(百日咳最长潜伏期)内,两组百日咳罹患率、发病距接种平均天数、平均痉咳天数均无差别(P>0.2);三个月内疫苗保护率为62.11%,表明百白破应急接种控制百日咳爆发点疫情安全有效。 |
| English Abstract: |
This paper reports the results of the effects of the emergent vaccination with DTP vaccine to control the outbreak of pertussis. Objects of observation were 4~6 years old children of kindergarten having pertussis vaccination and exposed history.The children were at random divided into two groups:76 children were vaccinated with DTP vaccine and 72 children were inoculated with placebo.
The results of observation:there was no strong and abnormal reaction in the vaccinated children; two weeks and three months after emergent vaccination with DTP vaccine, GMT antibody of pertussis were increased 18.14 and 4.73 times more than before vaccination respectively. There were no differences of the attack rates average days from vaccination to onset, average days of spasmodis cough(P>0.2) within 21 days after vaccination between the two groups. The protection rate was 62.11% three months after vaccination.The results showed that the emergent vaccination with DTP to control the outbreak of pertussis was safe and effect ire. |
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