| 李树人,王德焕,韦丽,郭立华,王哲,王惠琴,张桂霞,刘桂珍,孙铁滨,张树生,都洋,谢奉瑜.猩红热轻症化与病原探讨（附135例报告）[J].Chinese journal of Epidemiology,1990,11(6):348-351 |
| 猩红热轻症化与病原探讨（附135例报告） |
| A Study on Atypical Scarlet Fever |
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| DOI： |
| KeyWord: 猩红热 乙型溶血性链球菌 |
| English Key Word: Scarlet fever β-hemolytic streptococcus |
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| Abstract: |
| 对1987年哈尔滨市传染病院收治的135例猩红热病人进行了分析。0~15岁以下儿童发病占75.65%,男性高于女性。对129例进行检验,乙型溶血性链球菌检出率为46.51%,均为A群,对28株进行分型,结果1、4、8/25型占92.8%。药敏试验结果81.58%对氨苄青霉素和先锋霉索敏感,21.05%的菌株耐青霉素,临床表现有明显的轻症化趋势:37℃以下占45.18%,无及轻度咽峡炎占30.37%,无莓样舌占40%。我们初步认为引起轻症化原因:1.长期广泛应角抗生素,使菌株发生变异.2.早期应用抗生素致使A群链球菌没有产生大量致病物质前就被抑制或杀灭。3.由于第一个因素的存在,可能会使隐性感染者数量增加,一旦感染A群链球菌,由于机体存在一定的免疫力,亦可使临床症状变轻。 |
| English Abstract: |
An analysis of 135 cases of scarlet fever in Harbin Municipal infection hospital in 1987 was carried out.The patients of 0~15 years old were 75.65%, the males were higher than the females. All the patients had atypical clinical manifestation. 45.18% of them were no fever. 30.37% no angina and 40% no strauberry-like tongue-The 60 strains of β-hemolytic streptococcus were isola ted from 129 cases(positive rate 46.51%). 49 strains of them were identificated as Biotype idemti-fication was carried out in 28 strains of them. They are all Group A. 14, 6 and 6 strains as biotype 1, 4 and 8/25 respectively-The results of antibiotics resistent test showed that strains which-were susceptible to ampicillin and cephalosporin were 81.58% and the strains of resistant penicillin were 21.05%.
Some causes of atypical clinical manifestations were discussed. |
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