| 秦怀金,李绍忱.脑血栓形成危险因素的病例对照研究[J].Chinese journal of Epidemiology,1991,12(6):354-356 |
| 脑血栓形成危险因素的病例对照研究 |
| Case Control Study on Risk Factors of Cerebral Thrombosis |
| Received:May 05, 1990 Revised:August 17, 1990 |
| DOI： |
| KeyWord: 脑血栓形成 病例对照研究 条件Logistic回归分析 |
| English Key Word: Cerebral thrombosis Case control study Conditional logistic regression |
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| Abstract: |
| 采用1:1配比病例对照研究设计方法,探讨脑血栓形成的致病危险因素或保护因素。所选110个病例均是经CT检查确诊的新发病人。在单因素分析和多元逐步回归分析的基础上,进行条件Logistic回归分析,结果表明:在α=0.01水平上选出三个致病危险因素和一个保护因素。它们分别是:高血压(β=3.46,OR=7.57)、腹部皮脂厚度(β=3.21, OR=3.77)、脑卒中家族多发现象(β=2.25, OR=12.64)和高HDL2-C水平(β=-2.99 OR=0.16)。此外,本研究还对偏倚的控制及调查数据的质量进行了讨论与评价。 |
| English Abstract: |
In order to explore the pathogenic risk factors or protective factors of cerebral thrombosis, 1:1 matched case control study was done in 110 cases diagnosed by computerized tomography(CT).Both cases and controls were selected from several provincial and municipal hospitals in Jinan, Shandong Province, China.Every case was matched with one control on sex, race, age, occupation, residental area, educational level and economic status.
31 factors were analysed and 9 risk or protective factors were found by univariate analysis and multiple stepwise regression.Using the same 9 factors as independent variables, conditional logistic regression was performed and 4 factors were confirmed as pathogenic risk factors or protective factor of cerebral thrombosis (α=0.01).They are high blood pressure (β=3.46, OR=7.57), abdominal skinfold thickness (β=3.21, OR=3.77), familial aggregation of slroke (β=2.25, OR=12.64)and high level HDL2C(β=-2.99, OR=0.16).Moreover, reliability of collective data and control or biasses were evaluated and discussed. |
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