| 黄介枚,吴承民,孔繁钧,廖华乐,何伯钧,梁乃棠,何兆池,黄渭泉,罗均明,郭永文,黄祖星.乙型肝炎疫苗纳入计划免疫程序的研究[J].Chinese journal of Epidemiology,1992,13(1):1-4 |
| 乙型肝炎疫苗纳入计划免疫程序的研究 |
| Immunization of Hepatitis B Vaccine Integrated with EPI Schedule in Children |
| Received:January 22, 1991 Revised:April 07, 1991 |
| DOI： |
| KeyWord: 免疫应答 儿童免疫程序 联合免疫 乙型肝炎疫苗 |
| English Key Word: Immune response Children immunization schedule Simultaneous administration Hepatitis B vaccine |
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| Abstract: |
| 本文对乙型肝炎疫苗(HBV)纳入计划免疫的儿童免疫程序进行了研究,探索了HBV与现行程序中的其他疫苗的免疫应答性。在顺德县三个乡镇进行了现场试验,对180名新生儿分为三组,按三种免疫程序进行接种,并检测免前、免后血清学抗体。结果各组不同程序的抗-HBs、白喉、破伤风、百日咳、脊髓灰质炎三价混合疫苗(TOPV)和卡介苗(BCG)抗体的阳转率、几何平均滴度(GMT)均无显著的差别;HBV纳入计划免疫程序后,第3针与麻疹疫苗(MV)同时接种免疫应答良好。表明HBV纳入计划免疫程序是可行的,血清学能达到预期效果。 |
| English Abstract: |
| We studied the immunization of hepatitis B vaccine integrated with of EPI. 180 children(0~9 months of age) from three towns of Shunde County were randomly divided in to three groups (two trial groups and one control group). Which were vaccinated by three different immunization schedule. The serum antibodies to different vaccines were measured before and after immunization. The results show that the seroconvertion rate and GMT of each EPI vaccine are conformed with, the expected EPI indexes. The seroconvertion rate of anti-HBs antibody is found no significantly different among the three groups. The titres of pertussis agglutinating and three types polio neutralizing antibody is higher in trial groups than that in the control group. We conclude that the immunization of hepatitis B vaccine can be integrated into the EPI schedule. And third dose of hepatitis B vaccine can be simutaneously given with measles vaccine. |
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