| 刁连东,谢广中,王树巧,周立,王爱莲,周生华,梁曰志,黄浦泉,周玉芹.百白破混合制剂免疫持久性研究[J].Chinese journal of Epidemiology,1992,13(1):26-29 |
| 百白破混合制剂免疫持久性研究 |
| Study on Immune Persistency of Combined Diphtheria-Pertussis-Tetanus (DPT) Triple Vaccine |
| Received:March 05, 1991 Revised:May 10, 1991 |
| DOI： |
| KeyWord: 百白破混合制剂 血清学效果 免疫持久性 |
| English Key Word: Diphtheria-Pertussis-Tetanus triple vaccine Serological effect Continuity of immunization |
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| Abstract: |
| 70~80年代末,在观察基地比较吸附DPT间隔1月、2月接种2针和未吸附DPT接种3针、2针的免疫效果和免疫持久性,经血清学效果测定表明,四组儿童基免后能产生良好的白喉、破伤风抗体应答,而接种非吸附DPT儿童的百日咳抗体产生较差。加免后,三种抗体明显上升,白喉抗体至少可持续8年,破伤风抗体可维持5年左右,而百日咳抗体仅能维持3年左右。另对吸附DPT间隔2月接种2针与未吸附DPT接种3针比较,基免后白喉、破伤风、百日咳三种抗体均以吸附DPT效果较好,加免后则无显著差异。 |
| English Abstract: |
| Immune efficacy and persistancy were studied by comparation of two-dose immunization of adsorbed DPT at one and two month interval and two & three dose immunization of unadsorbed DPT during 1970s and 1980s.Serological investigation showed that antibody response to diphtheria, tetanus were elicited in four groups of children after primary immunization, but, the antibody response to pertussis was poor in children immunized with unadsorbed DPT.Three kinds of antibody titres were increased signaficantly after booster immunization Antibody perssist more than eight years for diphtheria, about five years for tetanus and only three years for pertussis. Comparation of two-cose immunization of adsorbed DPT at two months interval and three dose immunization of unadsorbed DPT showed that antibody response to diphtheria, pertussis and tetanus were satisfied in adsorbed DPT than in unadsorbed one after primary immunization, and there is no difference between primary and bosster immunization. |
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