B群脑膜炎奈瑟氏菌多位点酶电泳型及其流行病学意义

李新武; 胡绪敬; 高立慧; 王君

Abstract

李新武,胡绪敬,高立慧,王君.B群脑膜炎奈瑟氏菌多位点酶电泳型及其流行病学意义[J].Chinese journal of Epidemiology,1992,13(3):129-133

B群脑膜炎奈瑟氏菌多位点酶电泳型及其流行病学意义

Multilocus Enzyme Electrophoretic Types of Neisseria meningitidis Serogroup B and Their Epidemiologic Significances

Received:November 01, 1990 Revised:December 30, 1990

DOI：

KeyWord: B群脑膜炎奈瑟氏菌多位点酶电泳型克隆群体结构

English Key Word: Neisseria meningitidis serogroup B Multilocus enzyme electrophoretic types Clonal population structure

FundProject:卫生部医学科学研究基金资助课题

Author Name	Affiliation
Li Xinwu	Institute of Epidemiology and Microbiology, Chinese Academy of preventive Medicine, Beijing
胡绪敬	Institute of Epidemiology and Microbiology, Chinese Academy of preventive Medicine, Beijing
高立慧	Institute of Epidemiology and Microbiology, Chinese Academy of preventive Medicine, Beijing
王君	Institute of Epidemiology and Microbiology, Chinese Academy of preventive Medicine, Beijing

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Abstract:

为了阐明自70年代以来在我国11个省和2个直辖市内从流脑病人和带菌者中所分离的B群脑膜炎奈瑟氏菌(Nm)之间的流行病学关系,采用多位点酶电泳技术研究了57株病人菌株和45株带菌者菌株的多位点酶电泳型和克隆群。初步发现,上述菌株可分为69个电泳型(ET)和13个克隆群。其中I克隆群最为重要,因为从70年代以来,它代表了63.7%的所试的全部菌株,并且代表了77.2%的病人菌株,它在地理地区分布上也相当广泛。另外,还有一个明显的趋向,即是从1984年以后,越来越多的病人菌株集中于I克隆群,而且优势ET也出现在I克隆群的复合ET₁和ET₂₄中。当同病人菌株相比较时,上述带菌者菌株显示了更复杂的不同的基因型,只有40%的菌株属于上述I克隆群和优势ET。

English Abstract:

In order to expound the epidemiologic relationshipes between the strains of Neisseria meningitidis serogroup B isolated from patients and carriers, 57 case and 45 carrier isolates were collected in 11 provinces and 2 municipalities of China since the 1970s and their multilocus enzyme electrophoretic types and clonal population structures were studied by multilocus enzyme electrophoresis. It was primarily found that the above strains could be divided into 69 electrophoretic types (ET) and 13 clones. Among others, the clone I was the most important one, because the clone I represented 63.7% of all strains tested and 77.2% of the case isolates and its district distributions were quite wide since the 1970s. In addition, it was an obvious tendency that more and more of the case isolates gathered up the clone I since 1984 and the predominant ETs also occured in the complex ET₁ and ET₂₄ of the clone I.As compared with the case isolates, the above carrier isolates displayed more heterogenetic types.Only 40% of all carrier isolates belonged to the above clone I and predominant ETs.

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