| 裘云庆,何南祥,周绍聪,孔慧琴,王引福,闵志立.儿童对乙型肝炎疫苗加强接种的免疫应答[J].Chinese journal of Epidemiology,1992,13(5):278-281 |
| 儿童对乙型肝炎疫苗加强接种的免疫应答 |
| Immune Response to Hepatitis B Revaccination in Children |
| Received:October 18, 1990 Revised:May 08, 1991 |
| DOI： |
| KeyWord: 乙型肝炎疫苗 加强接种 免疫应答 |
| English Key Word: Hepatitis B Vaccine revaccination Immune response |
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| Abstract: |
| 观察了经乙型肝炎疫苗初免的38名儿童对乙型肝炎疫苗加强接种的免疫效果。疫苗加强接种后97.4%(37/38)儿童产生了免疫应答,接种后3周、3月及6月的抗-HBs水平由接种前的33.6IU/L,分别增至824.1、407.7及193.6IU/L,平均增高24.5、12.1和5.8倍,加强接种后3周抗-HBs水平达到高峰,3月及6月时抗-HBs水平比3周时分别下降50.5%和76.5%。加强免疫的应答效果主要由初免的免疫应答状态所决定。本文显示,儿童用10μg乙型肝炎疫苗加强接种能获得良好的免疫应答效果。 |
| English Abstract: |
| In this report, we investigated the efficacy of revaccination with hepatitis B vaccine in thirty-eight children after primary immunization. The results showed that anti-HBs immune response developed in 37 children after revaccination, with a response rate of 97.4% (37/38).The geometric mean titres (GMTs) of anti-HBs at 3rd weeks, 3rd and 6th month after the booster dose reached 824.1, 407.7 and 193.6IU/L, which were 24.5, 12.1 and 5.8 times higher than those before the booster dose (33.6IU/L), respectively. The peak levels reached at 3rd week after revaccination. However anti-HBs levels declined rapidly, the percentage of antibody decrease were 50.5%, 76.5% at 3rd and 6th month after booster dose, respectively. The immune response to revaccination gave a strong correlation to the primary immunization. In conclusion, our fingings indicated that a good response to revaccination with a dose of 10ug of hepatitis B vaccine in children were observed. |
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