| 徐慧文,李东升,徐经武,王学良,门伯媛,郑全庆,刘蓬勃,宋全江,高海燕,庄贵华,王文娟,唐晓红,王科,陶明.国产血源性乙肝疫苗的远期效果评价[J].Chinese journal of Epidemiology,1992,13(6):362-365 |
| 国产血源性乙肝疫苗的远期效果评价 |
| Evaluation of Long-term Efficacy on Plasma-derived Hepatitis B Vaccine |
| Received:August 20, 1990 |
| DOI： |
| KeyWord: 乙肝疫苗 保护效价 抗体应答 |
| English Key Word: Hepatitis B vaccine Protection rate Anti-HBs |
| FundProject: |
| Author Name | Affiliation | | Xu Huiwen | Department of Epidemiology, Xian Medical University | | 李东升 | Department of Epidemiology, Xian Medical University | | 徐经武 | Department of Epidemiology, Xian Medical University | | 王学良 | Department of Epidemiology, Xian Medical University | | 门伯媛 | Department of Epidemiology, Xian Medical University | | 郑全庆 | Department of Epidemiology, Xian Medical University | | 刘蓬勃 | Department of Epidemiology, Xian Medical University | | 宋全江 | Department of Epidemiology, Xian Medical University | | 高海燕 | Department of Epidemiology, Xian Medical University | | 庄贵华 | Department of Epidemiology, Xian Medical University | | 王文娟 | Department of Epidemiology, Xian Medical University | | 唐晓红 | Department of Epidemiology, Xian Medical University | | 王科 | Department of Epidemiology, Xian Medical University | | 陶明 | Department of Epidemiology, Xian Medical University |
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| Abstract: |
| 1986年4月至1990年5月用随机、双盲和有安慰剂对照的严格实验设计,在西安市郊区对265名5~9岁儿童进行国产血源性乙肝疫苗远期效果评价。疫苗组抗体峰值在T12,随后则下降。抗-HBs阳性率下降缓慢,抗-HBs几何均值下降急骤,但与安慰剂组相比均有显著差别。抗-HBs峰值高低及应答时间早晚与随后抗体持续时间长短呈正相关关系。四年观察结果显示疫苗对HBV感染的保护率为80%,如针对HBsAg而言,保护率为100%。 |
| English Abstract: |
| From April 1986 to May 1990, 265 pupils aged 5 to 9 years in Xian suburbs were studied to evaluate long-term efficacy of plasma-derived hepatitis B vaccine made in China. Anti-HBs titers in vaccine group reached the highest at twelfth month after the first injection and decreased afterwards. The positive rate of anti-HBs decreased slow, but geometric mean titers of anti-HBs fell sharply. Compared with placebo group, the differencem were all significant. The peak anti-HBs titers and the respons time positively correlated withs the persistence of anti-HBs. 4 years' observation showed that protection rate of hepatitis B vaccine against HBV infection was 80%. Protection rate was 100% if HBsAg was only considered. |
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