| 杨工,高玉堂,季步天,郑树,金凡,刘希永,高汝聂.青年人大肠癌与中老年人大肠癌的比较病例对照研究[J].Chinese journal of Epidemiology,1993,14(6):341-345 |
| 青年人大肠癌与中老年人大肠癌的比较病例对照研究 |
| Comparison between Large Bowel Cancer in Young People and that in Middle-aged and Old-aged People |
| Received:January 20, 1993 |
| DOI： |
| KeyWord: 肿瘤，大肠 对比研究 |
| English Key Word: Large bowel cancer Comparative study |
| FundProject:本课题受上海市科委科学技术发展基金资助部分受国家“八五”攻关项目资助 |
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| Abstract: |
| 本研究通过比较影响不同年龄组大肠癌发病的危险因素,说明青年人与中老年人大肠癌的可能病因学差异。结果表明:①>40岁组大肠癌与环境因素(主要是饮食、营养因素)的联系性比≤40岁组密切;②家族遗传因素对≤40岁组大肠癌的发病影响比>40岁组高2倍以上。提示大肠癌发病是环境因素与遗传易感性的累积效应,但各自的作用度在不同年龄组大肠癌中存在差异性。 |
| English Abstract: |
| In order to understand the difference in risk factors of large bowel cancer in different age groups, a population-based case-control study including two age groups, one group with the age of ≤ 40 (180 cases and 184 controls). And the other group with the age of >40 (1148 cases and 1161 controls), was conducted in Shanghai. The study indicated that:1. The patients of age >40 with large bowel cancer had closer relationship with the environmental factors (esp. dietary and nutritional factors) than the patients of age ≤ 40. 2. The familial genetic risk factor which affected development of the cancer in younger group was two-fold higher than that in elder group. The results suggested that both genetic and environmental factors influenced the occurrence of the cancer, and the role of the genetic factor in ≤ 40-yr group and that of the environmental factors in >40-yr group appeared to be important. |
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