| 赵宁,俞顺章.我国吸烟与肺癌关系的Meta-analysis——15个病例对照研究的合并分析[J].Chinese journal of Epidemiology,1993,14(6):350-354 |
| 我国吸烟与肺癌关系的Meta-analysis——15个病例对照研究的合并分析 |
| Meta-analysis of Smoking and Lung Cancer in China: Combined Analysis of Fifteen Case-control Studies |
| Received:February 03, 1993 Revised:February 25, 1993 |
| DOI： |
| KeyWord: Meta-analysis 肺肿瘤 |
| English Key Word: Meta-analysis Lung neoplasms |
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| Abstract: |
| 应用Meta-analysis方法对国内15个有关吸烟与肺癌病例对照研究进行了定量综合分析。累积病例为5703例,对照为5669例。采用Peto氏和Dersimonian and Nan Laird二氏模型方法处理数据。吸烟因素合并OR(吸烟与不吸烟对比)在男性为3.01(2.63~3.46),PAR为56.84%;而在女性合并OR为2.32(2.02~2.66),PAR为33.10%、吸烟量、吸烟年限、开始吸烟年龄与患肺癌OR值间存在剂量反应关系。患鳞癌的合并OR为4.79(4.02~5.70)、PAR为65.44%,而患腺癌的OR为1.02(0.87~1.20)、PAR为0.99%。另对影响本次分析的可能偏倚和混杂因素进行了讨论。 |
| English Abstract: |
| In the present paper, 15 case-control studies on the relation between smoking and lnng cancer in China were analyzed by means of Meta-analysis method, The cumulative cases and controls were 5703 and 5669, respectively. Peto's model and Der Simonian and Nan Laird model were applied to process data. The pooled OR (smoking vs no smoking) was 3.01 (95%CI:2.63~3.46) in males and 2.32 (95% CI:2.02~2.66) in females. The PAR was 56.84% in males and 33.10% in females. There was significant dose-response relation between the amount of smoking, the years of smoking, the age at start of smoking and the OR for developing lung cancer. The pooled OR of squamous carcinoma was 4.79 (95%CI:4.02~5.70), PAR was 65.44%. The pooled OR of adenocarcinoma was 1.02 (95%CI:0.87~1.20), PAR was 0.99%. |
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