| 陈贤辉,胡真,柔玉莲,王健夫,杨天英,张巧云,朱宝兰,黄曼瑜.固相放射免疫分析法在流脑人群抗体监测及临床血清学诊断的应用研究[J].Chinese journal of Epidemiology,1993,14(6):366-370 |
| 固相放射免疫分析法在流脑人群抗体监测及临床血清学诊断的应用研究 |
| Application of SP-RIA in the Antibody Surveillance and Serologic Diagnosis of Epidemic Cerebrospinal Meningitis |
| Received:March 26, 1993 Revised:June 28, 1993 |
| DOI： |
| KeyWord: 流行性脑脊髓膜炎 固相放射免疫分析法（SPRIA） 血清学诊断 |
| English Key Word: Neisseria Meningitis SP-RIA Serologic diagnosis |
| FundProject: |
| Author Name | Affiliation | | Chen Xianhui | Institute of Epidemiology and Microbiology, Chinse Academy of Preventive Medicine, Beijing, 102206 | | 胡真 | Institute of Epidemiology and Microbiology, Chinse Academy of Preventive Medicine, Beijing, 102206 | | 柔玉莲 | Institute of Epidemiology and Microbiology, Chinse Academy of Preventive Medicine, Beijing, 102206 | | 王健夫 | Institute of Epidemiology and Microbiology, Chinse Academy of Preventive Medicine, Beijing, 102206 | | 杨天英 | 河南省卫生防疫站 | | 张巧云 | 广东省卫生防疫站 参加工作的还有北京市、江苏、辽宁、四川、安徽等省市卫生防疫站 | | 朱宝兰 | 河南省卫生防疫站 | | 黄曼瑜 | 广东省卫生防疫站 参加工作的还有北京市、江苏、辽宁、四川、安徽等省市卫生防疫站 |
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| Abstract: |
| 报导固相放射免疫分析法(SPRIA)在健康人群A群流脑血清APS-IgG抗体水平的监测、A群流脑菌多糖菌苗免疫持久性的观察以及临床血清学诊断的应用结果。同IHA、BCA和ELISA等常用的流脑抗体测定方法比较。SPRIA具有更好的特异性和敏感性,而且可以精确定量。显示SPRIA在流脑防治和科研工作中良好的实用价值。 |
| English Abstract: |
| This paper reports the effectness of SP-RIA in the antibody surveillance on population, the observation of immune persistence after vaccination with Group A Nesseria meningococcal capsular polysaccharide vaccine, as well as its use in the serological diagnosis of Nesseria meningitis. In comparison with other assays used presently, SP-RIA might be better and more sensitive for quantitative assay of the antibody. The results showed the practical value of SP-RIA in the study of epidemiology and serology of epidemic cerebrospinal meningitis. |
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