| 刘佩莉,陆嘉良,江峰.292名孕妇人巨细胞病毒感染危险因素研究[J].Chinese journal of Epidemiology,1994,15(2):83-86 |
| 292名孕妇人巨细胞病毒感染危险因素研究 |
| Study on Risk Factors of 292 Pregnant Women infected with HCMV |
| Received:February 02, 1993 Revised:May 03, 1993 |
| DOI： |
| KeyWord: 人巨细胞病毒 激活感染 危险因素 宫内感染 |
| English Key Word: Human cytomegalovirus Reactivation Risk factors Intrauterine infection |
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| Abstract: |
| 292份母婴血清用ELISA法检测HCMV IgG与IgM抗体,拟了解孕妇激活感染的危险因素。发现上海市孕妇与婴儿感染率与激活感染率各为98.97%、3.77%与96.92%、1.71%.孕妇文化程度在中学以上其分娩婴儿的IgM抗体阳性率仅为低于此水平的1/2.8.孕妇怀孕胎次≥ 3次的RR(相对危险度)是怀1胎的5.67倍,其分娩婴儿IgM阳性率的RR为1.89倍。孕妇有病理性生产史者IgM阳性率的RR是正常或无生产史者的3.59倍,其婴儿的RR为1.59倍。孕妇的年龄、初潮年龄、职业与IgM抗体关系有待研究。根据母婴间血清IgM分布相关分析,相关系数为0.93,提示HCMV存在母婴间传播。 |
| English Abstract: |
| This paper is to determine the risk factors of reactivation by HCMV during pregnancy for improving child birth and bringing-up. A total of 292 paired sera were collected from mothers and their infants in Shanghai and were tested for IgG and IgM by ELISA. The positive rates of HCMV IgG and IgM were 98.97%, 96.97%and 3.77%, respectively in mothers and infants. The rate of IgM was 1.49% in infants whose mothers' education were above the high school level, whereas it was 4.17% whose mothers' educational degree was lower than that grade, and the relative ratio (RR) was 2.8. The number of previous pregnancies were closely associated with the positive rate of IgM. In infants born to mothers at first pregnancy, the positive rate was 1.96%, whereas in infants born to mothers at third pregnancy it increased to 3.70%, RR was 1.89. In pregnant women who were known to have postmortem or premature deliveries before the positive rate was 9.09%, whereas it was 2.53% in pregnant women at first pregnancy, the RR was 3.59. The rates of their infants were 3.03% and 1.90%, respectively, the RR was 1.59. The frequency of IgM antibody in 292 sera of mothers was correlated with that in their infants. It showed that HCMV might be transmitted from mother to fetus. |
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