肝癌危险因素的相互作用研究

赵宁; 俞顺章; 孙伟明

Abstract

赵宁,俞顺章,孙伟明.肝癌危险因素的相互作用研究[J].Chinese journal of Epidemiology,1994,15(2):90-93

肝癌危险因素的相互作用研究

Interaction among the Relative Risk Factors of Primary Liver Cancer in A Case-Control Study

Received:July 03, 1993

DOI：

KeyWord: 肝癌相互作用危险因素

English Key Word: Primary hepatocellular carcinoma Rik factors Interaction

FundProject:

Author Name	Affiliation
Zhao Ning	School of Public Health, Shanghai Medical University, Shanghai 200032
Yu Shunzhang	School of Public Health, Shanghai Medical University, Shanghai 200032
Sun Weiming	School of Public Health, Shanghai Medical University, Shanghai 200032

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Abstract:

笔者对原发性肝癌的主要危险因素饮水污染、乙型肝炎病毒感染、黄曲霉毒素污染间相互作用的关系进行了研究。运用相对危险度函数参数簇模型(从次相加结构到超相乘结构)来拟合病例对照资料,评判何种模型为佳,本文的结果提示:肝癌发生的主要危险因素饮水污染、乙型肝炎病毒感染、黄曲霉毒素(AFB₁)污染间存在协同作用;AFB₁与另两个肝癌主要危险因素乙型肝炎和饮沟塘水的联合作用似一种倾向于相加的结构,而乙型肝炎和饮沟塘水的联合作用似一种偏向于相乘的结构。不同模型间数量上的差别对病因学的解释和预防措施实践具有重要意义。

English Abstract:

This paper evaluates the combined effect of HBsAg, drinking water and aflatoxin B₁ (AFB₁) on the primary hepatocellular carcinoma (PHC) in a case-control study which was carried out in Fusui, Guangxi. We used relative risk model (from subadditive to supermultiplicative) to fit the relationship. The results showed that the combined effect of HBsAg infection and drinking pond-ditch water is nearly multiplicative, and the combined effect of HBsAg infection and AFB₁ intake as well as drinking pond-ditch water and AFB₁ intake were nearly additive.

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