| 王珊珊,吴春刚,李远贵,汪爱勤,阎永平,肖乐义,陈友绩.国产血源乙肝疫苗免疫效果及保护持久性研究[J].Chinese journal of Epidemiology,1994,15(3):154-157 |
| 国产血源乙肝疫苗免疫效果及保护持久性研究 |
| Evaluation on Efficacy of plasma-derived Hepatitis B Vaccine and persistence of protective level after Vaccination |
| Received:June 10, 1993 Revised:November 15, 1993 |
| DOI： |
| KeyWord: 乙型肝炎疫苗 抗-HBs |
| English Key Word: Hepatitis B vaccine anti-HBs |
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| Abstract: |
| 1990年10月至1993年5月以随机、双盲和安慰剂对照的实验设计,在西安市某军校300名HBV血清学指标均阴性的大学生中,对国产5个生物制品研究所的乙型肝炎血源疫苗作了免疫效果及保护持久性研究。按0、1、6方案在人群中免疫之后,定期采血观察抗-HBs动态并对各组人员进行随访观察发病情况。结果表明5个生物制品研究所的乙肝疫苗在抗-HBs出现的时间,滴度、下降等方面均无显著差异。抗-HBs峰值均在首次免疫后12个月,到24个月时阳性率下降约10%,而滴度下降80%。5组乙肝疫苗总保护率为79.22%。 |
| English Abstract: |
| From October 1990 to May 1993, 300 students aged 18 to 20 years in VI xian were studied to evaluate the efficacy of plasma-derived hepatitis B vaccine made in five facedtories. AntiHBs titer in 5 vaccinated groups reach the highest at the tuelfth month after the first injection and decreased afterwards. The positive rate of anti-HBs decreased slowly, but the titer of anti-HBs fell sharply. Compared with the control group, the differences were all significant. The results showed that the efficacies of hepatitis B vaccine made in five factories were similar. The protection rate of hepatitis B vaccine against HBV infection was 79.22%. |
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