| 宋慧军,李伟,单丽娟,张作儒.应用ELISA法评价狂犬病疫苗免疫后的血清和流行病学效果[J].Chinese journal of Epidemiology,1994,15(3):162-164 |
| 应用ELISA法评价狂犬病疫苗免疫后的血清和流行病学效果 |
| Using ELISA to Evaluate the Serologic and Epidemiologic Effect following Rabies Vaccination |
| Received:April 03, 1993 Revised:May 08, 1993 |
| DOI： |
| KeyWord: ELISA 抗狂犬病病毒抗体 信函调查 |
| English Key Word: ELISA Anti-rabies antibody Mailed epidemiologic inquiries |
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| Abstract: |
| 对动物侵伤者接种狂犬病疫苗后,用ELISA检测血清中抗体,并于一年后对接种者信函调查狂犬病发病情况,借以探讨该检测方法用于血清及流行病学效果的评价。信调应答率85%,其中抗体阳性组的狂犬病病死率0.24%(1/415),显著低于抗体阴性组的3.16%(3/95)(P=0.022)。抗体阳性组的病死者系狂犬咬伤颌面部、未处理伤口、疫苗6针,潜伏期28天,血清抗体第28天P/N值为3.27。 |
| English Abstract: |
| After vaccinating the people bitten by animals against rabies, we have examined their serum antibodies by using ELISA. One year later, we sent a mail to everyone of them inquiring if he had contracted rabies. The response rate was 85%. The case fatality rate of the positive antibody proup was 0.24% (1/415). The case fatalitv rate of the negative antibody group was 3.16 (3/95). It showed that there was significant difference in the case fatalitv rate of rabies between the two groups, (P=0.022). The dead person of the positive antibody group was bitten on his cheek by a rabid dog. He had not cleaned his wound. He had received 6 injections of rabies vaccines. His incubation period was 28 days. The P/N of serum antibody on the 28st day was 3.27. |
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