| 陈紫榕,刘小朋,李龙洋,林华,周善健,张国安.肝炎病毒重叠感染[J].Chinese journal of Epidemiology,1994,15(5):275-277 |
| 肝炎病毒重叠感染 |
| Superinfection of Hepatitis Viruses |
| Received:May 07, 1993 Revised:November 05, 1993 |
| DOI： |
| KeyWord: 肝炎病毒 重叠感染 |
| English Key Word: Hepatitis viruses Superinfection |
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| Abstract: |
| 185例HBV感染者,用ELISA法检测抗-HAV-IgM和抗-HCV。HBV感染者的HAV、HBV二重感染率为17.30%,HBV、HCV二重感染率为3.24%,HAV、HBV、HCV三重感染率为0.54%。32例HAV和HBV二重感染者,HBeAg 28例转阴;与153例单纯HBV感染者57例转阴比较,有显著性差异(P<0.05)。32例甲、乙型肝炎二重感染者,肝功复常天数(30.3±12.1)与230例单纯甲型肝炎复常天数(25.5±13.5)比较,也有显著性差异。HBV和HCV二重感染以及HAV、HBV、HCV三重感染者,也使HBeAg转阴,病情重、病程长。这些结果提示,甲、乙、丙型肝炎重叠感染比单一感染者的预后差,不少甲型肝炎慢性化可能是重叠感染乙型肝炎或/及丙型肝炎的缘故。 |
| English Abstract: |
| Using ELISA method, anti-HAV-IgM and anti-HCV were determined in 493 blood donors and 192 patients with HBV infection. The positive rate of anti-HCV in blood donors was 1.62%. The superinfection rates of HBV and HAV, HBV and HCV, HBV, HAV and HCV in patients with HBV infection were 16.7%, 3.13% and 0.52%, respectively. The incidence of hepatitis B viral replication marker was found to be lower in patients with superinfection of types A and B and/or C hepatitis viruses than in those with HBV infection alone. The prolonged course was found to be longer and the degree severer in patients with superinfection of types A and B and/or C hapatitis viruses than in those with HAV or HBV or HCV infection alone. The results suggest that those patients with superinfection of types A and B and/or C hepatitis viruses showed poor prognosis and prolonged course, and many patients with chronic Type A hepatitis resulted from superinfection HBV and/or HCV. |
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