| 杜国有.广西百色地区肝病患者及受血者HCV感染现状调查[J].Chinese journal of Epidemiology,1994,15(5):278-281 |
| 广西百色地区肝病患者及受血者HCV感染现状调查 |
| An Investigation on the Present Situation of HCV Infection Patients with Liver Diseases and in Blood Recipients in Baise District of Guang Xi |
| Received:March 27, 1993 Revised:July 26, 1993 |
| DOI： |
| KeyWord: 丙型肝炎病毒 丙型肝炎病毒抗体 肝病 输血 |
| English Key Word: Hepatitis C virus Anti-HCV Liver diseases Transfusion |
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| Abstract: |
| 笔者应用ELISA法对广西百色地区179例各类肝病患者及41例受血者血清进行了抗-HCV检测。结果各类肝病抗-HCV阳性率为17.9%,受血者抗-HCV阳性率为31.7%。在急性肝炎(急肝)、慢性肝炎(慢肝)、肝硬化和肝癌中,抗—HCV阳性率各为4.3%(1/23)、12.8%(10/78)、28.6%(12/42)和25.0%(9/36)。抗-HCV阳性率有随肝病慢性化而增高的趋势,肝硬化的抗-HCV阳性率明显高于急肝或慢肝(P<0.05),而肝癌的抗—HCV阳性率与急肝或慢肝相差不显著(P>0.05或0.1),且发现HBsAg阴性肝病者的抗-HCV阳性率明显高于HBsAg阳性患者(P<0.05),肝病患者抗-HCV的检出率与ALT活性无关(P>0.05)。在受血者中,抗-HCV的检出率与受血次数、ALT活性关系非常密切。因此,加强对HCV的检测是当前预防输血后肝炎的紧迫任务。 |
| English Abstract: |
| ELISA was used to detect anti-HCV antibody in 179 serum samples of patients with various types of liver diseases and 41 serum samples of blood recipients in Baise district of Guang Xi. The results showed that 17.9% of patients with various types of liver diseases and 31.7% of blood recipients were anti-HCV positive. Among patients with liver diseases, the anti-HCV positive rate was 4.3% (1/23) in acute hepatitis (AH), 12.8% (10/78) in chronic hepatitis (CH), 28.6% (12/42) in liver cirrhosis (LC) and 25.0% (9/36) in hepatocellular carcinoma (HCC). As liver diseases became chronic, the anti-HCV positive rate tended to rise. The anti-HCV positive rate in LC was significantly higher than that in AH or CH (P<0.05). The anti-HCV positive rata in HCC was not significantly different from that in AH or CH (P>0.05 or 0.1). It was found that the anti-HCV positive rate in HBsAg-negative patients was significantly higher than that in HBsAg-positive patients (P<0.05). The anti-HCV positive rate in liver diseases was not related to ALT (P>0.05). In blood recipients, the anti-HCV positive rate was closely related to the number of transfusion and the activity of ALT. |
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