| 王束玫,李绍忱,赵跃进,郝培良,贾崇奇.儿童单纯性先天性心脏病之危险因素及作用方式的探讨[J].Chinese journal of Epidemiology,1994,15(5):304-307 |
| 儿童单纯性先天性心脏病之危险因素及作用方式的探讨 |
| The Study of the Dengerous Factors of the Simple Heart Disease in Children and Its Action Mode |
| Received:June 10, 1993 Revised:December 22, 1993 |
| DOI： |
| KeyWord: 先天性心脏病 病因 对比研究 通径分析 |
| English Key Word: Congenital heart disease Etiolgy Comparative study Path analysis |
| FundProject: |
| Author Name | Affiliation | | Wang Shumei | Dept. of Epidemiology, Shandong Medical University, jinan 250012 | | Li Shaochen | Dept. of Epidemiology, Shandong Medical University, jinan 250012 | | Zhao Yuejin | Dept. of Epidemiology, Shandong Medical University, jinan 250012 | | 郝培良 | Dept. of Epidemiology, Shandong Medical University, jinan 250012 | | 贾崇奇 | Dept. of Epidemiology, Shandong Medical University, jinan 250012 |
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| Abstract: |
| 不伴有其他器官畸形的单纯性先天性心脏病(简称先心病)为多基因遗传病,其环境因素目前尚不明了,病因与先天性心脏病间作用方式更未见报道。本研究采用1:1配比病例—对照研究,对168对儿童之父母孕前和孕期多方面因素进行了调查。经单因素分析从55个变量中筛选出19个可疑危险因素。后经条件Logistic回归分析从19个变量中筛选出8个危险因素(α=0.05)。并对此8个危险因素进行通径分析以探讨各因素与先天性心脏病之间的作用方式。 |
| English Abstract: |
| The simple congenital heart disease is a multiple genetic disease. Its environmental factors are still unclear. The mode of action between the causes and congenital heart disease hasn't reported yet. This study used 1:1 case-control study and multiple factors were investigated in 168 pairs of parent before conception and the period of conception. First, using single factor analysis, the 19 suspicious risk factors were obtained from 55 factors (α=0.10). Second, using conditional logistic regression selected 8 risk factors from 19 factors (α=0.05). Finally, analysis of 8 risk factors were carried out by path analysis to explore the mode of action between the causes and congenital heart disease. |
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