乙肝基因工程疫苗阻断HBV母婴传播的效果观察

杨超美; 陈丹林; 励世芳; 马凤鸣; 陈益; 白红; 向真; 王宏禧; 宋珍珠; 胡宗汉

Abstract

杨超美,陈丹林,励世芳,马凤鸣,陈益,白红,向真,王宏禧,宋珍珠,胡宗汉.乙肝基因工程疫苗阻断HBV母婴传播的效果观察[J].Chinese journal of Epidemiology,1994,15(6):343-345

乙肝基因工程疫苗阻断HBV母婴传播的效果观察

Interruption of Perinatal Transmission of HBV by Chinese Recombinant Hepatitis B Vaccine

Received:March 06, 1993 Revised:February 02, 1994

DOI：

KeyWord: 疫苗

English Key Word: Vaccines

FundProject:

Author Name	Affiliation
Yang Chaomei	Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu 610031
Chen Danlin	Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu 610031
Li Shifang	成都妇幼保健院
马凤鸣	成都妇产科医院
陈益	自贡市卫生防疫站
白红	Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu 610031
向真	Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu 610031
王宏禧	Sichuan Provincial Hygiene and Epidemic Prevention Center, Chengdu 610031
宋珍珠	中国药品生物制品检定所
胡宗汉	成都妇产科医院

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Abstract:

对国产痘苗病毒乙肝基因工程疫苗(北京生物制品研究所研制)和地鼠卵巢细胞乙肝基因工程疫苗(长春生物制品研究所研制)进行阻断乙肝母婴传播的效果观察,剂量为20μg/支×3,接种HBsAg和HBeAg均阳性母亲的新生儿各40例,观察时间≥9个月者分别为33例和29例。结果:全部新生儿均无局部或全身不良反应,T₁时抗—HBs阳转率分别为3.0%和13.8%;T₉时达高峰,分别为78.8%和79.3%;疫苗保护率分别为79.2%和80.2%;抗—HBs滴度(S/N均值)T₉时为高峰,分别为113.04和99.11。各组中均有1例抗—HBs和HBsAg同时持续阳性;并分别有1例和2例抗-HBs均持续阴性。结果表明国产乙肝基因工程疫苗均有良好的安全性和免疫原性,其阻断乙肝母婴传播的效果较同剂量血源疫苗好,与30μg血源疫苗的阻断效果相近。

English Abstract:

Sixty-two infants who were born from HBsAg and HBeAg both positive mothers were vaccinated with 20μg/dose recombinant hepatitis B vaccine, which was made in Beijing Institute of Biologic Products (Vaccinia virus recombinant hepatitis B vaccine) and Changchun Institute of Biologic Products (Chinese hamster ovary cells recombinant hepatitis B vaccine), at 0, 1, 6 months. All the babies were followed up for 9 or 12 months. The results showed that the protective rates of Beijing vaccine and Changchun vaccine were 79.2% and 80.2%, respectively, the positive rates of anti-HBs were 78.8% and 79.3%, respectively. Local or systemaic reactions were not found in all the babies 3 days after injection. These results suggested that the Chinese recombinant hepatitis B vaccine was safe and effective. It was better than the plasma vaccine with the same dose.

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