| 胡昭烈,滕洪范,韩敏,王秀英,刘敬珍.婚前接种乙型肝炎疫苗阻断HBV母婴传播的效果观察[J].Chinese journal of Epidemiology,1994,15(6):346-348 |
| 婚前接种乙型肝炎疫苗阻断HBV母婴传播的效果观察 |
| Obeservation on Prevention of Hepatitis B Virus Transmission from Mother to Baby by Hepatitis B Vaccine |
| Received:October 06, 1993 Revised:January 02, 1994 |
| DOI： |
| KeyWord: HBV 乙肝疫苗 |
| English Key Word: HBV Vaccines |
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| Abstract: |
| 6年追踪随访婚前接种乙肝疫苗和对照组母亲的新生儿42人,结果免疫成功母亲的婴儿6个月血清抗—HBs阳性率为90.00%(9/10),且无1人感染HBV,而两组婚前和婚后HBsAg、HBsAg/HBeAg阳性母亲的婴儿依次为20.00%(2/10)及18.18%(4/22),显著低于前者(P<0.01),但HBsAg阳性率各为70.00%(7/10)、68.18%(15/22)。表明婚前乙肝疫苗免疫的“双阻断”作用可部分打破HBV“夫妇—母婴—人群”的传播链。 |
| English Abstract: |
| Forty-two new-born infants whose mothers had been given HBV vaccine before marriage were undergone medical examination for six years. The results showed that the six-month seroconversion rates of anti-HBs among those infants, whose mothers had been immunized successfully, were 90.00% (9/10), and no one was infected by HBV. But the rates of those infants whose mothers were found to be HBsAg(+) and HBsAg/HBeAg(+) before or after marriage were 20.00% (2/10) and 18.18% (4/22), respectively, being much lower than the former. The rates of HBsAg(+) were 70.00% (7/10) and 68.18% (15/22), respec-tively. This led to the conclusion that immunization with HBV vaccine before marriage will partly break the HBV transmission chain of "couples-mother and her baby-population". |
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