| 孟宗达,孙德贵,逯好英,Copland J,徐东刚,刘彩云,牛建章,陈素良,王树丛,陈淑芬,田茶,马贤凯,孙永德,Gowans EJ.丙型肝炎病毒再感染与初次感染对比研究[J].Chinese journal of Epidemiology,1995,16(2):74-77 |
| 丙型肝炎病毒再感染与初次感染对比研究 |
| A Comparative Study of Primary and Re-infection with Hepatitis C |
| Received:September 14, 1993 Revised:February 14, 1994 |
| DOI： |
| KeyWord: 丙型肝炎 初次感染 再感染 乙型肝炎病毒核糖核酸 |
| English Key Word: Hepatitis C Primary infection Secondary infection HCV RNA Immunity |
| FundProject:本项研究得到国家科委和河北省科委及卫生厅科研资金资助 |
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| Abstract: |
| 用套式PCR法检测HCVRNA,对比研究了HCV再感染与初次感染。10例初次感染HCV者,9例为临床型肝炎,1例亚临床型,首次ALT升高距输血的时间为15~60天(平均37.9±13.9);抗-HCV和HCV-RNA阳性1年以上分别为10/10和7/10。5例再感染者,4例为临床型肝炎,1例亚临床型,ALT首次升高距输血时间为30~46天(平均34.8±6.4),抗-HCV和HCV RNA阳性1年以上分别为5/5和3/5。结果表明,HCV再感染与初次感染在临床表现、ALT异常、抗-HCV和HCV RNA阳性持续时间等均无明显差异,提示HCV感染后诱发的免疫力较差,再感染仍可发病。 |
| English Abstract: |
| A nested polymerase chain reaction (PCR) was used to assess HCV re-infection and primary infection. In 10 hepatitis cases defined as primary infection, 9 showed clinical hepatitis, and 1 case was subclinical; the interval between transfusion and elevation of alanine aminotransferase (ALT) Ievels was 15~60 (37.9+13.9) days. 10/10 and 7/10 were persistently positive for anti-HCV and HCV RNA for more than 1 year respectively. Similarly, in 5 cases defined as re-infection, 4/5 showed clinical hepatitis, the interval between transfusion and elevation of ALT was 30~46 (34.8±6.4) days, and 5/5 and 3/5 were pensistently positive for anti-HCV and HCV RNA for more than 1 year respectively. All 5 re-infected recipients showed abnormal ALT. In conclusion, there was no significant difference (P>0.05) in the aspect of the clinical figure, ALT abnormality, the duration of anti -HCV and HCV RNA etc. Resulting from primary or re-infection with HCV, suggesting that primary infection fail to induce a Protective immune response. |
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