肝炎病毒感染与骨髓移植

黄晓军; 郭乃榄; 郑蕊; 范韫明; 史琪; 张耀臣; 陆道培

Abstract

黄晓军,郭乃榄,郑蕊,范韫明,史琪,张耀臣,陆道培.肝炎病毒感染与骨髓移植[J].Chinese journal of Epidemiology,1995,16(3):166-170

肝炎病毒感染与骨髓移植

Hepatitis Virus Infection and Bone Marrow Transplantation

Received:November 18, 1994 Revised:February 24, 1995

DOI：

KeyWord: HBV HCV 骨髓移植

English Key Word: HBV HCV Bone marrow transplantation

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Author Name	Affiliation
Huang Xiao-jun	Institute of Hematology BMU Beijing, 100044
Guo Nai-lan	Institute of Hematology BMU Beijing, 100044
Zheng Rui	Institute of Hematology BMU Beijing, 100044
范韫明	Institute of Hematology BMU Beijing, 100044
史琪	Institute of Hematology BMU Beijing, 100044
张耀臣	Institute of Hematology BMU Beijing, 100044
陆道培	Institute of Hematology BMU Beijing, 100044

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Abstract:

肝炎病毒感染是亚洲人包括中国的特殊感染问题,肝炎病毒感染与骨髓移植之间的关系尚不很明确。笔者通过对106例骨髓移植患者乙型、丙型肝炎病毒感染及其与临床结果的综合分析,发现骨髓移植后患者乙型、丙型肝炎病毒感染率分别为7/106(6.6%)、65/106(61.3%),乙型、丙型肝炎病毒活动均可致轻到中度肝功能上升,1例HBV、HCV混合感染患者因急性肝功能衰竭死亡,但无论乙型或丙型肝炎病毒感染均不影响骨髓的植活,亦不导致急、慢性移植物抗宿主病及肝静脉阻塞综合征发病率上升,因而肝炎病毒感染并非骨髓移植禁忌症,但肝炎病毒感染的防治仍是我们面临的一重大课题。人类重组干扰素可防治丙型肝炎病毒活动,笔者对此进行了初步探讨。

English Abstract:

Hepatitis virus infection is a special problem in China and the role of Hepatitis virus infection in allogeneic bone marrow transplantation (BMT) is not well-defined. In this study, 106 BMT patients were included for analysis of the role of virus infection in allo-BMT. Seven and 65 of 106 patients were found to have HBV infection and HCV infection, respectively. Neither HBV infection and HCV infection interfered with the engraftment of bone marrow cells nor increased the rate of AGVHD, CGVHD, VOD. Neither HBV infection nor HCV infection prohibited allo-BMT. But Hepatitis virus infection can cause mild to moderate liver dysfunction, even death because of acute liver function failure, active prevention and treatment of hepatitis virus infection remains necessary. In this respect, rh-interferon is useful.

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