4~7月龄婴儿麻疹胎传抗体及初次接种麻疹疫苗免疫应答的研究

刘白玉; 冯增欣; 徐爱强; 李世瑞; 王常银; 秦玲; 臧大学

Abstract

刘白玉,冯增欣,徐爱强,李世瑞,王常银,秦玲,臧大学.4~7月龄婴儿麻疹胎传抗体及初次接种麻疹疫苗免疫应答的研究[J].Chinese journal of Epidemiology,1995,16(5):263-265

4~7月龄婴儿麻疹胎传抗体及初次接种麻疹疫苗免疫应答的研究

A Study on the Level of Antibody against Measles through Maternal-fetal Transfer and the Immuno-Response to Measles Vaccine among 4 to 7 Month olds

Received:December 22, 1994 Revised:February 14, 1995

DOI：

KeyWord: 麻疹疫苗免疫应答

English Key Word: Measles vaccine Immune response

FundProject:

Author Name	Affiliation
Liu Bai-yu	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
Feng Zeng-xin	烟台市芝罘区卫生防疫站
Xu Ai-qiang	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
李世瑞	烟台市芝罘区卫生防疫站
王常银	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
秦玲	Shandong Provincial Hygiene and Epidemic Prevention Station, Jinan 250014
臧大学	烟台市芝罘区卫生防疫站

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Abstract:

笔者对143名4~7月龄婴儿麻疹胎传抗体及其对麻疹疫苗的免疫应答情况进行了研究,结果表明:4~7月龄婴儿麻疹胎传抗体的阴性率为75.00%~94.87%,且6~7月龄婴儿较4~5月龄婴儿的阴性率更低(χ²=5.11,P<0.05);而4~7月龄婴儿初免麻疹疫苗后,其免疫成功率为84.38%~100.00%,6~7月龄婴儿的免疫成功率显著高于4~5月龄的婴儿(χ²=5.37,P<0.05),GMT在各月龄组婴儿中的差异亦存在显著性意义(F=5.40,df=3,P<0.01)。另外,初免麻疹疫苗前麻疹抗体的滴度对免疫应答结果有明显的影响。综合以上结果,笔者认为要减少1岁内婴儿(尤其是9月龄以下婴儿)麻疹的发病,应将麻疹疫苗的初免时间提月龄。

English Abstract:

A total number of 143 infants at the age of 4 to 7 months from Yantai city-Shandong was selected for the study of antibody level against measles by maternal-fetal transfer and immuno-res-ponse to measles vaccine in October of 1993. The results showed that the negative rates of maternal-fetal antibody among infants of 4, 5, 6 and 7 month olds were 75.00%, 81.25%, 94.87%and 90.91%, respectively. The positive rates and geometric mean titers (GMTs) for immuno-response to measles vaccine were 92.86%, 84.38%, 97.44%, 100.00% and 55.17, 42.41, 69.95, 71.46, respectively. There was significant lower immune response to measles vaccine in infants who had high titer (>1:2) than those who had low titer (≤ 1:2) of maternal-fetal antibody (χ²=88.38, P<0.001). In order to decrease the number of measles cases under 1 year old (especially under 9 month-old), the author suggested that the primary immunization for measles vaccine should be started at 6 month olds.

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