| 李瑛,顾晓萍,杨明明,申素琪,丁婉华.口服避孕药与妇女高血脂和高血压的关系[J].Chinese journal of Epidemiology,1995,16(5):285-288 |
| 口服避孕药与妇女高血脂和高血压的关系 |
| Epidemiological Study on the Association between Oral Contraceptive and Female Hyperlipemia and Hypertension |
| Received:October 25, 1994 Revised:December 20, 1994 |
| DOI： |
| KeyWord: 口服避孕药 高血脂 高血压 |
| English Key Word: Oral contraceptive Hyperlipemia Hypertension |
| FundProject: |
| Author Name | Affiliation | | Li Ying | Department of Epidemiology, Jiangsu Family Planning Institute, Nanjing 210029 | | Gu Xiao-ping | Department of Epidemiology, Jiangsu Family Planning Institute, Nanjing 210029 | | Yang Ming-ming | Department of Epidemiology, Jiangsu Family Planning Institute, Nanjing 210029 | | 申素琪 | Department of Epidemiology, Jiangsu Family Planning Institute, Nanjing 210029 | | 丁婉华 | Department of Epidemiology, Jiangsu Family Planning Institute, Nanjing 210029 |
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| Abstract: |
| 对连续服用国产1号避孕片(OC)5~25年的健康农村妇女999名及同期使用宫内节育器(IUD)妇女1 065名的脂代谢和血压均值进行对比,对高血脂和高血压患病率及危险性进行分析。结果表明:长期服用OC妇女TG、TC、HDL水平和高甘油三脂症的患病率高于IUD组P<0.01),而高胆固醇症与对照组差异无显著性。OC组的收缩压和舒张压均值分别比IUD组高6.57和3.24mmHg(1mmHg=0.133322kPa),但均保持在正常范围内。高收缩压和高舒张压患病率均高于对照组(P<0.01)。多元分析结果表明,消除混杂因素的影响后,长期服用国产1号OC对高甘油三酯和高收缩压症的作用尚未有显著性意义。 |
| English Abstract: |
This paper analyzed the mean of serum lipid and blood pressure, prevalence rates and risks of hyperlipemia and hypertension in 999 healthy rural women who had been taking Chinese No. 1 contraceptive pill for 5-25 years. Data was compared with those in 1 065 control subjects wearing I UDs in a series of cohort studies The results showed that the level of serum triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL) and hyperglyceridernia prevalence rate after long-term administration of contraceptive pill were significantly higher than that in control subjects (P<0.01), whice hypercholesterolemia prevalence rate did not increase significantly.
The mean of systolic pressure and diastolic pressure in taking-pill group were 6.57 mmHg and 3.24 mmHg (1mmHg=0.133322kPa) respectively, higher than that of control group,but still maintained in the normal range. The prevalence rates of systolic hypertension and diastolic hypertension were higher than that of control group (P<0.01). The results of multiple regression analysis suggested that long-term administration of Chinese No. 1 contraceptive pill had nc marked influence on female hyperlipemia and hypertension after dispelling the effect, caused by confounding factors. |
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