| 李东光,高晓虹,关宏伟,张翠莉,王珍,邢玮,杜长春,臧玉华,吴蓉.幽门螺杆菌感染及其它因素在弥散型和肠型胃癌发病中的意义[J].Chinese journal of Epidemiology,1995,16(5):299-302 |
| 幽门螺杆菌感染及其它因素在弥散型和肠型胃癌发病中的意义 |
| Relationship between Helicobacter Pylori Infection Other Factors and Diffuse-and Intestinal Type Stomach Carcinomas |
| Received:September 11, 1994 Revised:November 21, 1994 |
| DOI： |
| KeyWord: 幽门螺杆菌感染 对比研究 胃癌 |
| English Key Word: Helicobacter pylori infection Comparative study Gastric carcinoma |
| FundProject:本项研究为辽宁省归国博士起动基金项目 |
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| Abstract: |
| 采用配对病例对照研究设计,对幽门螺杆菌感染及其它因素对于胃癌不同Lauren氏病理分型的特定意义进行了研究。对95对按年龄、性别配对的病例对照的调查和检测结果表明:幽门螺杆菌感染率在病例组与对照组分别为77.5%和50.0%;病例按Lauren氏组织学分型分层后,肠型组的幽门螺杆菌感染的OR=5.75,P=0.001,而弥散型组OR=3.5,P=0.182。还发现家族史、血型A与弥散型胃癌有联系,而经济水平低、饮食不规律和进食快与肠型胃癌有联系。本文结果支持幽门螺杆菌感染是胃癌尤其是肠型胃癌的危险因素,并认为两型胃癌在疾病起源及表现特征方面有所不同。 |
| English Abstract: |
| To investigate the role of Helicobacter Pylori (HP) infection and other factors in the development of stomach carcinoma, a matched case-control study was Conducted in Dalian, China. A total number of 95 paired cases and controls were involved in the study. The cases were divided into two histological types:diffuse- and intestinal-type. IgG antibody of HP in the subjects was tested with ELISA method. The results revealed that the prevalences of HP infection in cases and in controls were 77.5% and 50.0%, respectively,and that the matched OR was 5.0 (2.08-12.01). The stratified analysis showed that the risk effect of HP in intestinal-type was more significant (OR=5.75, 1.99-16.63) than it in deffuse-type(OR=3.5,0.73-16.89). Cancer history within family and blood group A were associated with diffuse-type while the environmental factors such as low economic status, irregular eating and fast-eating habits were mainly associated with intestinal-type. We conclude from our findings that HP infection may play a role in the development of stomach cancer, especially for intestinal-type gastric cancer. The two Lauren's histological types of stomach cancer might be different in terms of pathogenesis and characteristics. |
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