| 王继先,贾卫华,李本孝,高智伟,徐钧,张景源.我国女性医用诊断X线工作者乳腺癌危险及其因素分析[J].Chinese journal of Epidemiology,1996,17(6):325-327 |
| 我国女性医用诊断X线工作者乳腺癌危险及其因素分析 |
| Risk and Influential Factors of Female Breast Cancer among Medical Diagnostic X-ray Workers in China |
| Received:August 29, 1996 Revised:September 09, 1996 |
| DOI： |
| KeyWord: 医用诊断X线工作者 乳腺癌 危险因素 |
| English Key Word: Medical diagnostic X-ray worker Breast cancer Risk factor |
| FundProject: |
| Author Name | Affiliation | | Wang Ji-xian | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 | | Jia Wei-hua | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 | | Li Ben-xiao | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 | | 高智伟 | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 | | 徐钧 | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 | | 张景源 | Institute of Radiation Medicine, Peking Union Medical College, Chinese Academy of Medical Sciences, Tianjin 300192 |
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| Abstract: |
| 为研究低剂量长期职业照射能否诱发妇女乳腺癌及癌发生的影响因素,作者对全国女性医用诊断X线工作者乳腺癌发病情况及危险因素作了队列研究及队列内病例对照研究。研究结果表明X线工作者乳腺癌的发生率显著高于对照组,其危险增高主要见于1960年前开始放射工作者、从事放射工作25年以上者及30岁以前开始放射工作者,发病年龄未见明显提前。因素分析表明与乳腺癌发生有显著相关的危险因素为乳腺累积剂量、乳腺癌家族史及肥胖,肥胖和未授乳这两个因素可能与职业X线照射有交互作用,它们的存在加强了辐射致乳腺癌的效应。 |
| English Abstract: |
| To study whether prolonged or repeated low-dose ionizing radiation could induce female breast cancer, we analyzed the incidence and risk factors of breast cancer among female medical diagnostic X-ray workers in China by cohort study and case-control study nested in the cohort. The risk of breast cancer enhanced significantly than the control group. It occurred in those who engaged in X-ray work before 1960, those who have been worked more than 25 years and those who are exposed before age 30, however, the age of onset cancer did not advance. The significant risk factors are accumulative radiation dose of the breast, obesity and family history of breast cancer. In addition, interaction could exists between obesity, non-lactation history and occupational X-ray exposure. |
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