吸烟者淋巴细胞染色体畸变和微核形成的观察

金银龙; 王汉章; 顾珩; 程义斌

Abstract

金银龙,王汉章,顾珩,程义斌.吸烟者淋巴细胞染色体畸变和微核形成的观察[J].Chinese journal of Epidemiology,1997,18(1):40-42

吸烟者淋巴细胞染色体畸变和微核形成的观察

Observation of Chromosome Aberration and Micronucleus Formation in Peripheral Blood Lymphocytes among Cigarette Smokers

Received:May 06, 1996 Revised:August 21, 1996

DOI：

KeyWord: 吸烟者染色体

English Key Word: Smoker Chromosome

FundProject:

Author Name	Affiliation
Jin Yin-long	Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing 100050
Wang Han-zhang	Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing 100050
Gu Heng	Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing 100050
程义斌	Institute of Environmental Health and Engineering, Chinese Academy of Preventive Medicine, Beijing 100050

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Abstract:

采用染色体畸变和微核分析两个具有相关性的遗传物质损伤观察指标，同时观察了男性健康吸烟者遗传物质的损伤情况。结果表明，吸烟组超倍体细胞单、染色单体型细胞畸变率、染色体型畸变率、细胞总畸变率、微核率、微核细胞率均显著高于非吸烟组。表明吸烟是诱发人体遗传物质损伤的重要诱变因素之一。

English Abstract:

Using two interrelated observation indices——chromosomal aberration and micronucleus analysis in peripheral blood lymphocytes to reflect damages of genetic material,were used to observe the status of genetic material damage in male smokers at the same time. The results showed that there were significant increase in hyperpolid cell rate, chromatid and chromosome aberration rates, total aberant cell rate and frequency of micronucleated cells as well as micronuleus in smoking group when compared to non-smoking group. This findings showed that cigarette smoking is one of the important mutagenic factors which caused damage to human genetic materials.

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