| 韩存芝,荆洁线,孙桂训,苗林,郭郢,赵先文,李春,郭晋纲.环境污染对居民细胞遗传物质损伤的调查研究[J].Chinese journal of Epidemiology,1997,18(2):83-85 |
| 环境污染对居民细胞遗传物质损伤的调查研究 |
| Study of Environmental Pollution and Damage of Cytogenetic Materials in Urban Residents |
| Received:September 15, 1996 Revised:November 07, 1996 |
| DOI： |
| KeyWord: 环境污染 细胞遗传物质 |
| English Key Word: Environmental pollution Cytogenetic materials |
| FundProject: |
| Author Name | Affiliation | | Han Cun-zhi | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 | | Jing Jie-xian | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 | | Sun Gui-xun | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 | | 苗林 | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 | | 郭郢 | 大同市环境保护研究所 | | 赵先文 | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 | | 李春 | 大同市环境保护研究所 | | 郭晋纲 | Department of Etiology, Shanxi Cancer Institute, Taiyuan 030013 |
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| Abstract: |
| 流行病学资料调查表明，大同市南郊区北村乡近年来恶性肿瘤死亡呈明显的上升趋势，为了探讨癌高发的原因，本文对该地区大气、地面水及居民饮水、蔬菜和人群血清的污染情况进行相关因素的分析调查。结果表明，大气中的苯并（a）芘（Bap）、悬浮颗粒物（TSP）及饮食中硝酸盐、亚硝酸盐均高于非污染区，地面水污染严重。同时该地区居民外周血淋巴细胞微核、畸变核及人群血清铜含量、铜/锌比值均明显高于对照区，差异均非常显著（P<0.01），并与该地区大气中Bap和TSP、饮食中的硝酸盐和亚硝酸盐成正相关。结果还表明，该地区居民外周血淋巴细胞的非程序DNA合成（UDS）试验的cpm值明显低于对照组，差异非常显著（P<0.001），并与大气、水源的污染因素成负相关。认为大同市北村乡地区近年来大气、水源的严重污染可能是该地区居民细胞遗传物质损伤及癌发病率增高的重要因素。 |
| English Abstract: |
| Recently,epidemiologic data have indicated that the number of deaths caused by malignant tumor presented a significantly rise in Beicun countryside of Datong city. In order to understand the causes of high incidence of cancer,factors were investigated and analyped related to air,river water,drinking water,vegetables and human serum. Results showed that Benzo (a)-pyrene (Bap), total suspended particulates (TSP)in air, nitrate, nitrite in drinking water and vegetables were all signifcantly higher in Beicun countryside region than those in controlled countryside region, respectively(P < 0.01-P< 0.001). The micronuclei (MN) and berration nucleus (AN) rates of cultured lymphocytes were significantly higher while cpm value of unscheduled DNA synthesis (UDS) test were significantly lower than those in controlled region among residents in Beicun countryside region, respectively (P < 0.01-P < 0.001). The micronuclei, abrerration nucleus rates and cpm value of cultured lymphocytes among residents in Beicun countryside were strongly correlated with Bap, TSP, nitrite and nitrate contents in determination samples. Our results suggest that the air and water source under serious pollution may serve as an important factor causing cytogenetic damage among residents and cancer death rise in Beicun countryside. |
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