先天性心脏病的遗传流行病学研究

刘长云; 童祥华; 杜玉华; 傅兴江; 郑国华; 马洪美

Abstract

刘长云,童祥华,杜玉华,傅兴江,郑国华,马洪美.先天性心脏病的遗传流行病学研究[J].Chinese journal of Epidemiology,1997,18(4):224-226

先天性心脏病的遗传流行病学研究

A Study on the Genetic Epidemiology of Congenital Heart Disease

Received:September 12, 1996 Revised:January 03, 1997

DOI：

KeyWord: 遗传度流行病学先天性心脏病

English Key Word: Heritability Epidemiology Congenital heart disease

FundProject:本课题为山东省计生委资助

Author Name	Affiliation
Liu Chang-yun	Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong 261031
Tong Xiang-hua	Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong 261031
Du Yu-hua	潍坊市计划生育研究所
傅兴江	Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong 261031
郑国华	Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong 261031
马洪美	Department of Pediatrics, Affiliated Hospital, Weifang Medical College, Shandong 261031

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Abstract:

为探讨先天性心脏病的遗传方式，对375例先天性心脏病进行了遗传流行病学研究，结果显示该病一级亲属患病率为6.9%，遗传度66.13%±1.13%；二级亲属患病率为1.7%，遗传度为38.25±8.3%，一、二级亲属加权平均遗传度为65.65±1.09%，遗传因素较为重要。在各级亲属患病中，患病率依次为一级亲属（6.9%）、二级亲属（1.7%）、一般群体（0.86%）。所以该病基本符合多基因遗传方式，遗传在决定先天性心脏病的易患性上起主要作用。

English Abstract:

In order to explore the genetic model of congenital heart disease (CHD),375 individuals of CHD were investigated.The results showed that the incidence of primary relatives was 6.9%, the heritability was 66.13 ±1.13%, the incidence of secondary relatives was 1.7% and the heritability was 38.25±8.3% respectively.The average heritability among primary,secondary relatives was 65.65±1.09% which suggested that the genetic factor played an important role in pathogenesis. The sequence of the incidence in the relatives showed:primary relatives (6.9%)> secondary relatives (1.7%)> distant relatives (0.86%) and was in accordance with polygenic incidence,suqqesting that gene play an important role in the liability variation of CHD.

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