| 熊小卫,刁连东,严旭玲,姜维平,冯捌晓,黄和兴.不同年龄人群对风疹疫苗的免疫应答研究[J].Chinese journal of Epidemiology,1997,18(4):227-229 |
| 不同年龄人群对风疹疫苗的免疫应答研究 |
| Immune Response of Rubella Vaccine in the Populations with Different Age Groups |
| Received:November 26, 1996 Revised:January 02, 1997 |
| DOI： |
| KeyWord: 风疹疫苗 免疫应答 |
| English Key Word: Rubella vaccine Immune response |
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| Abstract: |
| 作者报告了江苏省在风疹疫苗使用前人群的自然免疫状况，4岁以下年龄组血凝抑制（HI）抗体阳性率在25%以下，随着年龄的增长，自然免疫水平增高，13~25岁人群阳性率约在80%左右。接种风疹疫苗1月后，抗体100%阳转，GMT从免前的13.33上升至243.16，说明国产BRDⅡ株风疹减毒活疫苗具有良好的免疫原性。对于免前阳性人群，风疹疫苗接种后抗体亦有显著性上升。 |
| English Abstract: |
| The natural immunity status in different age groups was investigated. The positive rate of HI antibody under the age of 4 was less than 25%. The natural immunity level increased gradually with age and the positive rate of the antibody reached 80% among the group aged 13-25.Rate of seroconversion was 100% in any age group one month after immunization,and GMT rose from 13.33 to 243.16. It was suggested that immunogenicity of domestic attenuated live rubella vaccine BRD Ⅱ was satisfactory. For the population with positive antibody before immunization,the total GMT rose from 189.59 to 259.00 after vaccination and the difference between immunization before and after was highly significant. According to the above result,we suggested that the vaccination strategy for rubella among young children and women of child bearing age should be implemented. |
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