| 邵亚农,沈靖,谈永飞,姚才良,周炎,钮菊英,吴勤芳,朱鸣鸣,张国强,王心如,徐希平.脑梗塞家族聚集性的病因和流行病学研究[J].Chinese journal of Epidemiology,1997,18(5):275-278 |
| 脑梗塞家族聚集性的病因和流行病学研究 |
| A Study on The Etiology and Epidemiology of Familial Aggregation in Arteriosclerotic Cerebral Infarction |
| Received:May 10, 1997 Revised:June 20, 1997 |
| DOI： |
| KeyWord: 脑梗塞 家族聚集性 病因 流行病学 |
| English Key Word: Arteriosclerotic cerebral infarction Family members aggregation Etiology Epidemiology |
| FundProject: |
| Author Name | Affiliation | | Shao Ya-nong | Department of Behabilitation, Yixing People's Hospital, Yixing 214000 | | Shen Jing | 南京医科大学公共卫生学院 | | Tan Yong-fei | Department of Behabilitation, Yixing People's Hospital, Yixing 214000 | | 姚才良 | 南京医科大学公共卫生学院 | | 周炎 | Department of Behabilitation, Yixing People's Hospital, Yixing 214000 | | 钮菊英 | 南京医科大学公共卫生学院 | | 吴勤芳 | Department of Behabilitation, Yixing People's Hospital, Yixing 214000 | | 朱鸣鸣 | 南京医科大学公共卫生学院 | | 张国强 | Department of Behabilitation, Yixing People's Hospital, Yixing 214000 | | 王心如 | 南京医科大学公共卫生学院 | | 徐希平 | 哈佛大学公共卫生学院 |
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| Abstract: |
| 本研究通过遗传流行病学病例对照方法，对宜兴市214个家系（109个脑梗塞先证家系和105个对照家系）进行了脑梗塞家族史的遗传易感性研究，结果表明：病例和对照家系有良好的均衡可比性，病例组一级亲属总的患病率为5.12%，与对照组的1.63%相比，差异有非常显著性（χ2=16.41，P<0.01），不论其父母或同胞，均以病例亲属的患病率显著高于对照，而子女中两者无显著性差异；二项分布显示，脑梗塞家族中实际发病数超过其二项分布的理论概率范围，即脑梗塞的分布呈明显的家族聚集性；单因素和多因素logistic回归模型拟合也提示，遗传因素在脑梗塞发病中占有重要地位，并有剂量反应关系，其分离比、遗传度与冠心病和食管癌等慢性疾病接近。 |
| English Abstract: |
| A ease-control study including 214 pedigrees (109 cases and 105 controls) was carried out to explore the etiology of family aggregation of arteriosclerotic cerebral infarction in Yi-Xing city, March 1997. The results showed that the family member in both cases and control groups were comparable. The total prevalence rate of the first-degree relatives in eases was 5.12%, significantly higher than (1.63%) that noticed in controls, with χ2=16.40 (P<0.01). The same results was also found in their parents and siblings. Results from hinominal distribution analysis showed that the number of cases in the families of arteriosclerotic cerebral infarction was signficantly higher than the therotical range which indicated that there was significant familial aggregation in the occurance of arteriosclerotic cerebral infarction. Logistic regression model also showed that genetic factor was one of the most important risk factors in Yi-xing, Jiangsu. Dose-response was observed in this model. The heritability and the segregation ratio of arteriosclerotic cerebral infarction were the same as seen in other chronic diseases, such as coronary heart disease and esophageal cancer. |
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