脑梗塞危险因素的交互作用分析

周家仪; 沈靖; 邵亚农; 谈永飞; 姚才良; 徐希平

Abstract

周家仪,沈靖,邵亚农,谈永飞,姚才良,徐希平.脑梗塞危险因素的交互作用分析[J].Chinese journal of Epidemiology,1997,18(5):279-281

脑梗塞危险因素的交互作用分析

Analysis on the Interaction Among Agents in Arteriosclerotic Cerebral Infarction

Received:June 30, 1997 Revised:July 05, 1997

DOI：

KeyWord: 脑梗塞危险因素交互作用

English Key Word: Arteriosclerotic ceerbral infarction Etiology Interaction

FundProject:

Author Name	Affiliation
Zhou Jia-yi	School of Public Health, Nanjing Medical University, Nanjing 210029
Shen Jing	School of Public Health, Nanjing Medical University, Nanjing 210029
Shao Ya-nong	宜兴市人民医院康夏科
谈永飞	宜兴市人民医院康夏科
姚才良	School of Public Health, Nanjing Medical University, Nanjing 210029
徐希平	哈佛大学公共卫生学院

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Abstract:

本研究通过1：1配比病例对照研究，对脑梗塞危险因索之间的交互作用进行了分析。结果表明：脑梗塞的主要危险因素为TG、Lp （a）和BMI，而HDL-C是唯一的保护因素，Lp （a）与BMI进行分级后，仍可看出对脑梗塞的剂量效应关系，考虑到各因素间较强的相关关系，进一步对入选因素进行了对数线性模型拟合，结果显示：是否患脑梗塞与TC、TG、HDL-C、Lp （a）之间的交互作用显著，TC、TG、HDL-C和LDL-C之间两两均有交互作用，说明血脂因素之间的交互作用是确实存在的，但在何种水平上的交互作用最大，还需进一步的定量分析。

English Abstract:

An 1:1 matched case-control study including 105 arteriosclerotic cerebral infarction cases and 105 controls was carried out to estimate the etiologic interaction, in Yi-xing city, March 1997. Results showed that the major risk factors were high levels of serum TG, Lp(a) and BMI while serum level of HDL-C was the only protective factor. When several levels were divided on Lp(a) and BMI, a significantly dose response relation was found. Considering the correlation among serum concentration of lipids, we analysed the interaction of different factors, using Log-Linear models. Results showed that there were significant interactions between arteriosclerotic cerebral infarction and TC, TG, HDL-C and Lp(a). There were also interactions between TC, TG, HDL-C and LDL-C. However, the strongest interaction is expected to happen at what level remains further investigations.

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