| 王春俭,李东升.乙型肝炎疫苗免疫人群效果观察[J].Chinese journal of Epidemiology,1998,19(1):43-46 |
| 乙型肝炎疫苗免疫人群效果观察 |
| A Study on the Effectiveness of Hepatitis B Vaccine among the Vaccinated Population |
| Received:March 19, 1997 |
| DOI： |
| KeyWord: 乙型肝炎疫苗 免疫 |
| English Key Word: Hepatitis B vaccine Immunity |
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| Abstract: |
| 为评价乙型肝炎( 乙肝) 疫苗在人群中应用的效果, 采用多阶段整群系统随机抽样的方法, 对河南省13 个县市中的1 890 个家庭, 5 890 人进行乙肝疫苗接种情况的调查。发现接种疫苗者HBsAg 阳性率明显降低, 抗-HBs 阳性率明显升高。只接种1 针者无免疫保护作用; 2 岁内接种疫苗效果最好; 5 岁以下儿童中接种率达到70%时可使HBsAg 阳性率降低到1%以下。结果说明乙肝疫苗在人群中应用效果明显, 小年龄接种和全程接种对效果影响显著, 维持高的接种率才会使相应人群带毒率明显下降。 |
| English Abstract: |
| In order to identify the effect of hepat it is B vaccine in a vaccinated population, 5890 persons from 1890 families in 13 counties/ cities in Henan province were chosen for investigation under multistage cluster systematic sampling. All subjects were bled for HBsAg, ant-i HBs and ant-i HBc by RIA. The positive rate of HBsAg was significantly lower in vaccinates than in that non- vaccinates. There was no protective effect in those who only vaccinated for one dose. It was preferable to receive vaccination before the age of two years. If 70% of hepatit is B vaccine coverage was reached among those younger than 5 years old, the positive rate of HBsAg could reduce to 1% or even lower. Results showed that it was impor tant to ensure an earlier and full course vaccination with high cover age. |
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