两种乙型脑炎疫苗的免疫效果观察

郭万申; 李林村; 吴振溢; 曾贵金; 余福勋; 张彦平; 李林红; 荆瑞芳; 韩焕侠; 王文周

Abstract

郭万申,李林村,吴振溢,曾贵金,余福勋,张彦平,李林红,荆瑞芳,韩焕侠,王文周.两种乙型脑炎疫苗的免疫效果观察[J].Chinese journal of Epidemiology,1998,19(2):97-99

两种乙型脑炎疫苗的免疫效果观察

Analysis on the Immuno-Eff ects of Two Diff erent Japanese Encephalit is Virus Vacc ines

Received:June 10, 1997 Revised:August 10, 1997

DOI：

KeyWord: 流行性乙型脑炎灭活疫苗减毒活疫苗阳性率

English Key Word: Japanese e ncepha litis Inactiva ted v accine Liv e at tenuated v accine Po sitiv er ate

FundProject:

Author Name	Affiliation
Guo Wan- shen	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
Li Lincun	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
Wu Zhenyi	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
曾贵金	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
余福勋	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
张彦平	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
李林红	Health and Anti-epidemic Center of Henan Province, Zhengzhou 450003
荆瑞芳	郑州市金水区卫生防疫站
韩焕侠	郑州市金水区卫生防疫站
王文周	河南省西华县

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Abstract:

将 319名受隐性感染机会较少的 5～ 18月龄的婴幼儿分为两组,分别接种乙型脑炎 (乙脑 )灭活疫苗和减毒活疫苗。经间接免疫荧光法检测其血清抗体发现,免疫前血清抗体仅有 3.76%阳性。基础免疫后,两种疫苗的抗体阳性率分别增加至 59.56%和 56.0 8%,但尚不能达到保护性水平。 1年后加强注射 1针,1个月后阳性率分别增加至 94.62 %和 98.2 1%,GMT也明显增加,半年后,阳性率改变为 72.34 %和 94.74 %。减毒活疫苗在加强免疫后的免疫效果及持久性明显高于灭活疫苗。根据观察结果认为,乙脑灭活疫苗免疫,应基础免疫两针,间隔 7～ 10天,第二年加强免疫1针之后,间隔 1年再加强 1针。减毒活疫苗基础免疫 1针,第二年加强 1针,经 4～ 5年后再加强注射。由于减毒活疫苗高的免疫效果,较少的接种次数以及较高的安全性,适宜于广大地区推广应用。

English Abstract:

319 infants aged 5-18 months were divided in to 2 groups and immunized with Japanese encephalitis virus inactivated vaccine and live attenuated vaccine respec tively. Under thedetection of serum antibody, a 3. 76% serum antibody positive rate was revealed before the immunization. However, after the basic immuni zation the serum positive rates of the two vaccines reached 59. 56% a nd 56. 08% respectively but still under the protective level. The infants were then given booster injection one year later. The serum positive rates reached 94. 62% and 98. 21% respectively1 month later. When six months after the booster immunization, the positiverates were 72. 34%and 94. 74% r espectively. According to the result, the following immunization order was recommend.For inactivated vaccine: 2 injections are given with an interval of 7-10 days for basic immunization and boo ster immunization be given in the second and third years. For live attenuated vaccine:one injection is given for basic immunization then booster dosebe given in the second yea r and4-5 years later.

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