| 黄芬,董亚珞,王占英,赵桂珍,李颖,苏德元.沈阳地区不同人群HCV感染及HCV基因型分布研究[J].Chinese journal of Epidemiology,1998,19(3):134-137 |
| 沈阳地区不同人群HCV感染及HCV基因型分布研究 |
| Study on HCV Infection and the Distribution of HCV Genotypes in Different Populations in Shenyang Area |
| Received:October 31, 1997 Revised:November 25, 1997 |
| DOI： |
| KeyWord: HCV感染 HCV基因型 |
| English Key Word: HCV infection HCV genotypes |
| FundProject: |
| Author Name | Affiliation | | Huang Fen | Department of Infectious Disease, The Second Affiliated Hospital, China Medical University, Shenyang 110003 | | Dong Yaluo | 中国医科大学附属第一临床医院 | | Wang Zhanying | Department of Infectious Disease, The Second Affiliated Hospital, China Medical University, Shenyang 110003 | | Zhao Guizhen | Department of Infectious Disease, The Second Affiliated Hospital, China Medical University, Shenyang 110003 | | Li Ying | Department of Infectious Disease, The Second Affiliated Hospital, China Medical University, Shenyang 110003 | | Su Deyuan | Department of Infectious Disease, The Second Affiliated Hospital, China Medical University, Shenyang 110003 |
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| Abstract: |
| 应用酶联免疫检测技术，检测沈阳地区3 902例不同人群血清的抗-HCV，并应用引物特异PCR法对其中100例血清标本进行HCV基因分型。结果：正常人群抗-HCV阳性率为0.42%～1.66%；输血后及散发性肝炎(除外HAV、HBV、EBV、CMV感染)、乙型肝炎、肝炎后肝硬化(除外HBV感染)、原发性肝癌等组抗-HCV阳性率显著高于无输血史的非肝病病人组(P<0.01)；100例血清标本中HCV-Ⅱ型感染占58%、HCV-Ⅲ型27%、Ⅱ/Ⅲ混合型14%、未分型1%，正常人群HCV感染者中HCV基因型以Ⅲ型为主(80%)，丙型肝炎后肝硬化病人HCV基因型以Ⅱ型为主(91.7%)。提示：各类肝病病人是HCV感染的高危人群；沈阳地区HCV感染以Ⅱ型为主，其次为Ⅲ型及Ⅱ/Ⅲ混合型，HCV基因型可能与丙型肝炎病情轻重有关。 |
| English Abstract: |
| 3902 serum samples in different populations were tested for anti-HCV by ELISA.Among 100 samples of them,genotypes of HCV were detected by PCR with type-specific primers.The results showed:a)anti-HCV positive rates in general populations were 0.42%-1.66%;b)anti-HCV positive rates in the group of post-transfusion hepatitis and sporadic hepatitis (excluding HAV,HBV,EBV,CMV infection),hepatitis B post hepatitis cirrhosis (excluding HBV infection) and primary hepatocarcinoma were significantly higher than the group of patients without liver diseases or the group of patients without transfusion (P<0.01); c) in HCV genotyping,HCV-Ⅱ,HCV-Ⅲ,Ⅱ/Ⅲ mixed type were 58%,27%,14% respectively.The rate of infection with HCV-Ⅲ was 80% in normal population but 91.7% with type Ⅱ HCV in the group of patients with cirrhosis.These results suggested:(1)patients with different liver diseases were under high risk of HCV infection;(2)type HCV-Ⅱ was predominant followed by HCV-Ⅲ as well as Ⅱ/Ⅲ mixed in HCV genotype distribution of Shenyang area.Different genotypes of HCV might be related to the severity of hepatitis C. |
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