| 舒波,窦晓光,李颖,王兆荃.沈阳地区重型肝炎血清中庚型肝炎病毒核酸的检测[J].Chinese journal of Epidemiology,1998,19(3):168-169 |
| 沈阳地区重型肝炎血清中庚型肝炎病毒核酸的检测 |
| Detection of HGV RNA in Sera from Patients with Fulminant Hepatitis in Shenyang |
| Received:November 10, 1997 Revised:February 10, 1998 |
| DOI： |
| KeyWord: 庚型肝炎病毒 庚型肝炎病毒核酸 |
| English Key Word: HGV HGV RNA Fulminant hepatitis |
| FundProject: |
| Author Name | Affiliation | | Shu Bo | Department of Infectious Diseases, Second Clinical College, China Medical University, Shenyang 110003 | | Dou Xiaoguang | Department of Infectious Diseases, Second Clinical College, China Medical University, Shenyang 110003 | | Li Ying | Department of Infectious Diseases, Second Clinical College, China Medical University, Shenyang 110003 | | Wang Zhaoquan | Department of Infectious Diseases, Second Clinical College, China Medical University, Shenyang 110003 |
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| Abstract: |
| 为调查重型肝炎的庚型肝炎病毒(HGV)的感染状况。我们应用逆转录-巢式聚合酶链反应(Rt-nested PCR)检测了49例重型肝炎患者血清中的庚型肝炎病毒核酸(HGV RNA)。结果显示：8例 HGV RNA阳性(16.3%)，其中6例死亡(75%)；8例HGV感染的重型肝炎患者中7例重叠感染乙型肝炎病毒(HBV)或丙型肝炎病毒(HCV)，1例为单纯HGV感染。提示：HGV与其它肝炎病毒重叠感染及单纯HGV感染均可引起重型肝炎；而且其临床表现较重，病死率高。 |
| English Abstract: |
| HGV RNA was detected by Rt-nested PCR in sera from 49 patients with fulminant hepatitis.The results showed:a) HGV RNA positive rate was 16.3% (8/49) in patients with fulminant hepatitis including 4 subjects with HBV coinfection,1 subject with HCV coinfection,2 subjects with HBV and HCV coinfection and 1 subject with HGV infection alone.b)mortality in patients with fulminant hepatitis with HGV infection was 75% (6/8), suggesting that: a) both infection with HGV alone and super infections of other types of hepatitis virus can result in fulminant hepatitis. b) clinical manifestaitions of fulminant hepatitis with HGV infection may appear to be more severe and with higher mortality. |
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