分子标记物在肺腺癌预后评估中的意义

周宝森; 戴晓淳; 何安光; 杨春林; 朱继江

Abstract

周宝森,戴晓淳,何安光,杨春林,朱继江.分子标记物在肺腺癌预后评估中的意义[J].Chinese journal of Epidemiology,1998,19(4):231-233

分子标记物在肺腺癌预后评估中的意义

Molecular Marker As An Indicator in Presaging Prognosis of Human Lung Adenocarcinoma

Received:April 07, 1998 Revised:May 04, 1998

DOI：

KeyWord: 肺腺癌 p21蛋白 p53蛋白细胞增殖活性

English Key Word: Lung, adenocarcinoma p21 Protein p53 Protein Proliferating cell nuclear antigen(PCNA)

FundProject:国家八五科技攻关资助项目

Author Name	Affiliation
Zhou Baosen	Department of Epidemiology, China Medical University, Shenyang 110001
Dai Xiaochun	中国医科大学肿瘤研究所肺癌研究室
He Anguang	中国医科大学肿瘤研究所肺癌研究室
杨春林	中国医科大学研究生处
朱继江	中国医科大学病理学教研室

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Abstract:

对93例肺腺癌患者做分子流行病学研究, 应用免疫组织化学染色方法, 用Cox多因素回归模型, 分析p21蛋白、p53蛋白、细胞增殖活性(PCNA)与预后的关系。结果表明:肺腺癌p21蛋白阳性的, 预后不好, 表达阳性的死亡危险性是阴性的2.08倍;p53蛋白与肺腺癌预后无关;PCNA阳性百分比高的, 预后不好, 肺腺癌PCNA阳性百分比50%以上的死亡危险性是肺腺癌PCNA阳性百分比20%以下的3.27倍。

English Abstract:

The paper discusses 93 eases of human lung adenocarcinoma in terms of molecularepidemiology. The relationship between p21 protein and p53 protein and proliferationg cell nuclear antigen (PCNA) was analysed by immunohischemical methods. Prognosis by Cox model was used for prosnosis prediction of adenocarcinoma in human lung. Results showed that the prognosis of adenocarcinoma was poor when of p21 protein expression was positive and the relative ratio was 2.08. However, p53 protein expression was not related to the prognosis of adenocarcinoma. The bigher the positive rate of PCNA was, the poorer the prognosis of adenocarcinoma oppeared, with a ratio of 3.27.

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