儿童水痘血清流行率调查及其疫苗免疫效果

周铁群; 王剑锋; 邱平; 李长贵; 韩秀娟; 殷文武; 李志仁; 万卓越; 金艾顺; 张静; 黄丽娟; 王开利

Abstract

周铁群,王剑锋,邱平,李长贵,韩秀娟,殷文武,李志仁,万卓越,金艾顺,张静,黄丽娟,王开利.儿童水痘血清流行率调查及其疫苗免疫效果[J].Chinese journal of Epidemiology,1998,19(5):271-273

儿童水痘血清流行率调查及其疫苗免疫效果

Investigation on Sera Prevalence Rate of Varicella and Immunogenicity of Varicella Vaccine in HealthyChildren

Received:December 16, 1997 Revised:February 17, 1998

DOI：

KeyWord: 水痘流行率 Oka水痘疫苗免疫效果

English Key Word: Varicella Prevalence rate Oka varicella vaccine Immuner esponse

FundProject:

Author Name	Affiliation
ZHOU Tie-qun	National Institute for the Control of Pharma-ceutical and Biological Products, Beijing 100050
WANG Jian-feng	National Institute for the Control of Pharma-ceutical and Biological Products, Beijing 100050
QIU Ping	National Institute for the Control of Pharma-ceutical and Biological Products, Beijing 100050
LI Chang-gui	National Institute for the Control of Pharma-ceutical and Biological Products, Beijing 100050
韩秀娟	National Institute for the Control of Pharma-ceutical and Biological Products, Beijing 100050
殷文武	黑龙江省病毒病防治研究所
李志仁	黑龙江省病毒病防治研究所
万卓越	黑龙江省病毒病防治研究所
金艾顺	黑龙江省病毒病防治研究所
张静	黑龙江省病毒病防治研究所
黄丽娟	黑龙江省病毒病防治研究所
王开利	黑龙江省病毒病防治研究所

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Abstract:

为了解儿童水痘流行情况及水痘减毒活疫苗的免疫效果,采用全抗原ELISA方法对315名3～7岁儿童水痘的血清流行情况进行了调查,血清抗VZV-IgG阳性率为41.6%,且不同幼儿园中水痘流行情况有所不同,表现出明显的群体差异。同时对Oka株水痘减毒活疫苗在该人群的免疫效果进行了调查,结果表明该疫苗接种后无明显副反应,血清阳转率为85.1%。证明了减毒活疫苗有良好的安全性和有效性。

English Abstract:

A whole varicella virus antigen-ELISA method was used to investig ate the sera prev alence rate of var icella in 315 healthy children aged 3-7 years. Results showed that the sera positive rate of anti-VZV-I gG was 41.6%. Differ ent prevalence rates in differ ent kindergartens were noticed, character izing the differences of populations. I mmunog enicity of Oka strain attenuated varicella vaccine among children was also studied. No obvious adverse reactions were observed and the seraconversion rate was 85.1%.

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