| 袁曾麟,李凤祥,李亚楠,石继春.我国人群中抗b型流感嗜血杆菌多糖抗体水平的调查[J].Chinese journal of Epidemiology,1999,20(1):42-44 |
| 我国人群中抗b型流感嗜血杆菌多糖抗体水平的调查 |
| The investigation of natural antibody level toHaemophilus influenzae type b polysaccharide in China |
| Received:June 09, 1998 Revised:October 14, 1998 |
| DOI： |
| KeyWord: b型流感嗜血杆菌多糖 自然抗体 放射免疫法 |
| English Key Word: Hib-PRP Natural antibody Radio immunoassay |
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| Abstract: |
| 目的 调查中国人群中抗流感嗜血杆菌多糖（Ｈｉｂ-ＰＲＰ）自然抗体水平，为合理使用 Ｈｉｂ菌苗提供资料。方法 从７个省市收集１５９６份不同年龄组健康人群血清标本，用放射免疫方法检测抗 Ｈｉｂ-ＰＲＰ自然抗体水平。结果 甘肃、贵州、江西等地５岁以下婴幼儿平均抗体水平＜０．１μｇ／ ｍｌ，上海、广西、黑龙江等地相对较高。脐带血平均抗体含量为０．３６μｇ／ ｍｌ，６月～５岁儿童平均抗体含量为＜ ０．１５μｇ／ｍｌ，６岁至成人则达１～１．５μｇ／ｍｌ。结论 中国人群对Ｈｉｂ疾病的群体免疫力不高。６月～５岁儿童自然抗体水平最低，为 Ｈｉｂ疾病的高危人群。 |
| English Abstract: |
| Objective Investigation of natural antibody level to Haemophilus influenzae type b polysaccharide in China.Methods 1596 sera samples from cord(55 sera), infants(1383 sera), children (66 sera), adult (52 sera) and elderly (40 sera) were collected from different provinces and the natural antibody level to PRP was measured with a standardized radio immunoassay 125I-labeled PRP.Results Antibody level of infants under 5 year olds in different provinces was different. Levels of infants from Gansu, Guizhou, Jiang xi province were lower (≤0.07μg/ml)than from Shanhai, Guangxi and Heilognjiang. Comparison of antibody levels with different age groups showed that infants aged 6 months to 5 years having the lowest antibody level (<0.15μg/ ml). The level increased rapidly during 6-10 years of age (≥1.0μg/ ml). The levels of adults and elderly were about 1-1.5μg/ml.Conclusion General immunity against Hib disease were low in Chinese population. Children aged 6 months to 5 years old with lowest natural antibody level to PRP were the population under high risk. |
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