小儿肺炎支原体肺炎的细胞免疫和流行病学分析

赵惠芬; 李莉; 刘晓红

Abstract

赵惠芬,李莉,刘晓红.小儿肺炎支原体肺炎的细胞免疫和流行病学分析[J].Chinese journal of Epidemiology,1999,20(1):47-49

小儿肺炎支原体肺炎的细胞免疫和流行病学分析

Cellullar immunity and epidemiologic analysis of pediatric patients with Mycoplasma pneumonia

Received:October 16, 1998 Revised:December 10, 1998

DOI：

KeyWord: 支原体.肺炎细胞免疫白细胞介素受体

English Key Word: Mycoplasma pneumonia Celluler immunity Interleukin recepter

FundProject:

Author Name	Affiliation
ZHAO Huifen	首都医科大学附属北京友谊医院儿科 100050
LI Li	首都医科大学附属北京友谊医院儿科 100050
LIU Xiaohong	首都医科大学附属北京友谊医院儿科 100050

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Abstract:

目的　探讨肺炎支原体肺炎的发病机理，特别是与机体免疫功能紊乱的关系。方法对９０例住院的支原体肺炎患儿，根据其Ｘ线肺部受侵程度，分为重症组和轻症组，并设立了对照组，分别检测了各组极期和恢复期的Ｔ细胞亚群、血清可溶性白细胞介素－２受体（ＳＩＬ－２Ｒ）及天然杀伤细胞（ＮＫ) 数。结果　肺炎支原体肺炎极期和恢复期ＣＤ_４均下降，ＣＤ_８极期和恢复期均上升（ｔ＝２．６３，２．６６和２．７７，３．３６，Ｐ＜０.０５)。全部病人，无论极期还是恢复期ＳＩＬ－２Ｒ均显著高于正常，而在病的极期变化尤为明显（ｔ＝５．２６，３．１９,Ｐ＜０.０１）。检测还显示：ＳＩＬ－２Ｒ与病情有关，病情越重，增高越明显。结论　患支原体肺炎时存在细胞免疫功能紊乱，且检测ＳＩＬ－２Ｒ的水平可作为监测其严重程度的指标。流行病学资料表明发病年龄以１０～１４岁为多发。

English Abstract:

Objective　To understand the of immuno-reactions of pediatrics patients with Mycoplasma pneumonia.Methods 90 patients suffered from M. pneumonia were administered and divided into three groups: mild group, severe group, and normal control group. T cell subset parameters, natural killer cell and the serumsoluble interleukin-2 recepter of all of above were determined.Results Data showed: CD₄decreased at both acute and recovery stage of M. pneumonia, while CD₈ remar kably increased (t=2.63, 2.66, 2.77, 3.36, P<0.05). SIL-2R level of all patients also greatly increased (t=5.26, 3.19, P P <0.01), especially in the serious group.Conclusion There are disturbances of cell-immune in M.pneumonia. The level of SIL-2R can serve as monitor on the degree of severeness of M. pneumonia. The incidence M. pneumonia appeared highest in the 10-14 year-old group.

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