| 李忠佑,高长明,丁建华,王建东,王亚平,胡旭,刘体康,ToshiroTakezaki,KazuoTajima.[J].Chinese journal of Epidemiology,1999,20(2):88-90 |
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| Study on seroprevalence of Helicobacter Pylori infection among upper digestive tract cancer patients and their kindreds |
| Received:July 29, 1998 Revised:September 10, 1998 |
| DOI： |
| KeyWord: 幽门螺杆菌 上消化道癌 亲属对照 流行病学 |
| English Key Word: Helicobacter pylori Upper-digestive tract cancer Kindreds Epidemiology |
| FundProject:日本文部省国际学术研究癌症特别调查研究经费资助 |
| Author Name | Affiliation | | LI Zhongyou | Department of Virology,Jiangsu Institute of Cancer Research,Nanjing 210009 | | GAO Changming | Department of Virology,Jiangsu Institute of Cancer Research,Nanjing 210009 | | DING Jianhua | Department of Virology,Jiangsu Institute of Cancer Research,Nanjing 210009 | | 王建东 | Department of Virology,Jiangsu Institute of Cancer Research,Nanjing 210009 | | 王亚平 | Department of Virology,Jiangsu Institute of Cancer Research,Nanjing 210009 | | 胡旭 | 淮安市肿瘤防治办公室 | | 刘体康 | 邳州市卫生局 | | ToshiroTakezaki | 日本国爱知县癌中心研究所疫学部 | | KazuoTajima | 日本国爱知县癌中心研究所疫学部 |
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| Abstract: |
| 目的调查幽门螺杆菌（Hp）感染与上消化道癌危险性的关系。方法在江苏省淮安市和邳州市,应用HpIgG定量酶联免疫（ELISA）检测试剂盒,随机检测312例上消化道癌及其健康一级亲属对照人群外周血中抗HpIgG.结果①胃癌患者中HpIgG抗体水平（阳性率50.0%）高于贲门癌患者和食管癌患者（P>0.05,χ2检验）;贲门癌患者与食管癌患者之间,以上三类癌症病例与其自身亲属对照之间,差异亦不明显；②胃癌组病例与亲属同时感染Hp的阳性率（27.1%）显着高于贲门癌组和食管癌组（P<0.05）,后两组之间无明显差异。结论Hp感染在胃癌家族中存在明显家庭聚集现象,Hp感染与胃癌危险性的关系有待进一步观察。 |
| English Abstract: |
| ObjectiveIn order to analyse the association between Hp infection and the risk of upper-digestive tract cancer.MethodsIn Huaian and Pizou cities,Jiangsu province,Hp IgG quantitative-enzyme-immunoassay methods was used to identify IgG to H.pylori in the serum of 312 cases of upper-digestive tract cancer patients and their kindreds.Results⑴The level of IgG to H.pylori and the IgG positive rate (50.0%)in gastric cancer patients were both higher than that of cardia and esophageal cancer patients (P>0.05,χ2test)but no significant differences w ere observed between cardia and esophageal cancer patients,3 typies of cancer patients and their kindreds;⑵the overall positive rates of both patients and kindreds in gastric cancer families (27.1%)were significantly higher than that of cardia or esophageal cancer families (P<0.05)but no significant differences were observed between cardia and esophageal groups.ConclusionH .pylori infection w as not thought to be correlated with the development of gastric cancer,although higher clustering of Hp infection in families afflicted with gastric cancer was noticed. |
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