颧部褐青色痣危险因素的病例对照研究

汪治中; 卫连坤; 牟贤龙; 吴寅华; 薛广波; 蔡全才

Abstract

汪治中,卫连坤,牟贤龙,吴寅华,薛广波,蔡全才.颧部褐青色痣危险因素的病例对照研究[J].Chinese journal of Epidemiology,1999,20(2):102-103

颧部褐青色痣危险因素的病例对照研究

A case-control study on the risk factors in naevus fusco-caeruleus zygomaticus

Received:June 27, 1998 Revised:August 20, 1998

DOI：

KeyWord: 痣,褐青色病例对照研究危险因素

English Key Word: Naevus,fusco-caeruleus Case-control study Risk factor

FundProject:

Author Name	Affiliation
WANG Zhizhong	Department of Dermatology,Changhai Hospital,the Second Military Medical University,Shanghai 200433
WEI Liankun	Department of Dermatology,Changhai Hospital,the Second Military Medical University,Shanghai 200433
MU Xianlong	Department of Dermatology,Changhai Hospital,the Second Military Medical University,Shanghai 200433
吴寅华	Department of Dermatology,Changhai Hospital,the Second Military Medical University,Shanghai 200433
薛广波	第二军医大学流行病学教研室
蔡全才	第二军医大学流行病学教研室

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Abstract:

目的探讨颧部褐青色痣的发病危险因素。>方法对100例患者进行1：1配对的病例对照研究,通过条件logistic回归多因素和单因素分析筛选主要危险因素。结果该病患者有较高的家族史暴露率,提示该病有“遗传易感性”存在。环境危险因素有化妆品应用史和紫外线暴露史,但每一因素均不能解释所有病例。结论认为遗传易感性与环境危险因素的联合作用可以解释颧部褐青色痣的发病过程,遗传基因的定位与环境因素的联合研究对揭示颧部褐青色痣的病因具有重要意义。

English Abstract:

ObjectiveTo determine the risk factors of naevus fusco-caeruleus zygomaticus,a case-control study was conducted in 100 cases.Methods　The selection of major risk factors was through logistic regression and χ²-test.Results　It was suggested that the high exposed rate in the family history of objectives was related to “ genetic susceptibility”.Histories of using cosmetics and exposure to ultraviolet ray were identified as enviromental risk factors.However,there was no single factor that could completely explain the etiology of naevus fusco-caeruleus zygomaticus.ConclusionWe believe that coordinating effects of both susceptibility in genetics and enviromentalrtant in the discovery of the etiology of naevus fusco-caeruleus zygomaticus.

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