| 胡国庆,赖燕菲,魏兰芬,林军明,张峰.洁康手术消毒剂杀菌性能和毒性观察[J].Chinese journal of Epidemiology,1999,20(6):346-349 |
| 洁康手术消毒剂杀菌性能和毒性观察 |
| Laboratory observation on germicidal efficacy and toxicity of disinfectant Jiekang |
| Received:July 15, 1999 |
| DOI： |
| KeyWord: 醋酸氯己啶 杀菌效果 外科洗手消毒 |
| English Key Word: Cholrhexidine diacetate Germicidal efficacy Surgical hand washing |
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| Abstract: |
| 目的 为了解洁康手术消毒剂的杀菌活性和使用安全性。方法 按照１９９７ 年卫生部“消毒技术规范”（ 试行） 版规定的方法，对其杀灭金黄色葡萄球菌、大肠杆菌和手部自然菌进行了实验室和现场试验。结果 含醋酸氯己啶８０ｍｇ／Ｌ样液作用１ｍｉｎ，对悬液中大肠杆菌、金黄色葡萄球菌的平均杀灭率达９９.９９ ％,作用３ｍｉｎ 均达１００ ％。样品原液作用３ｍｉｎ 对手指皮肤表面污染的大肠杆菌的平均灭除率为９９.９８ ％,对自然菌的平均灭除率为９８.２１ ％,且消毒后均达到《医院消毒卫生标准》中Ⅰ、Ⅱ类环境医护人员手细菌菌落总数卫生标准要求。样品经５４ ℃恒温存放１４天，醋酸氯己啶的降解率为２.５４ ％,毒性检测结果表明无毒、对皮肤无刺激。和碘伏外科洗手消毒比较结果表明，其外科洗手消毒效果优于碘伏。结论 在使用浓度和作用时间下，可有效杀灭细菌，且手部皮肤表面残留菌数达到医院Ⅰ、Ⅱ类环境医护人员手细菌总数卫生标准要求 |
| English Abstract: |
| Objective To reveal the germicidal vitality and safety in use of surgial disinfectant Jiekang, a compound disinfectant containing 0.8% chlorhexidine diacetate and non-ionic surfactant.Method Following the standards of disinfective technique published by the Ministry of Public Health in 1997, experiments on observing the germicidal vitalitree of surgical disinfectant Jiekang, regarding killing Staphylococcus aureus Escherichia coli and natural bacteria both in laboratory and in the fields. Results Its diluted solution containing 80mg/L chlorhexidine diacetate could kill 99.99% of Escherichia coli and Staphylococcus aureus in 1 minute and 100% in 3 minutes. The average killing rate of its stock solution on E.coli and the natural bacteria on the skin of fingers were 99.98% and 98.21% respectively in 3 minutes. The total bacteria counts on hands after disinfection fulfilled the requirments of “ Hygienic standard for disinfection in hospitals” set by the Ministry of Health. The degrading rate of chlorhexidine diacetate was 2.54% after storing for 14 days at 54℃. The disinfectant showed no toxicity and no irritation to skin. It also showed better results than iodophor in the experiments on surgical hand washing. Conclusion Under the required concentration and period of disinfection, Jiekang surgical disinfectant seemed to have killed germ effectively, met the standards of survival germ counts on the surface of hand skin, and met the health on criteria and residnal germ total counts on hands of medical staff working in the Ⅰ and Ⅱ-type enviroment in hospitals. |
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