| 郝超,姜维平,王亚龙,陈文宇,沈洪兵,徐耀初.Ⅱ型糖尿病家族聚集性的流行病学研究[J].Chinese journal of Epidemiology,1999,20(6):360-363 |
| Ⅱ型糖尿病家族聚集性的流行病学研究 |
| An epidemiologic study on familial aggregation in non-insulin-dependent diabetes mellitus (NIDDM) |
| Received:May 25, 1999 Revised:June 02, 1999 |
| DOI： |
| KeyWord: Ⅱ型糖尿病 家族聚集性 流行病学 |
| English Key Word: Non-insulin-dependent diabetes mellitus Family aggregation Epidemiology |
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| Abstract: |
| 目的 探讨家族遗传因素在Ⅱ型糖尿病发生发展中的作用。方法 采用遗传流行病学病例对照研究方法，对常州市３５０ 个家系（１８４ 个Ⅱ型糖尿病先证家系和１６６ 个对照家系） 进行了Ⅱ型糖尿病的遗传流行病学研究。结果 病例组一级亲属总的患病率为３．４７ ％,与对照组的１.０３ ％ 相比，差异有非常显著性（χ２ ＝ １７.６６,Ｐ＜ ０.０１） ；无论其父母、同胞或子女，均以病例亲属的患病率显著高于对照； Ⅱ型糖尿病家族中实际发病数超过其二项分布的理论概率范围，即Ⅱ型糖尿病的分布呈明显的家族聚集性； 单因素和多因素ｌｏｇｉｓｔｉｃ 回归模型拟合也提示，家族史仍是Ⅱ型糖尿病的最主要危险因素。结论 遗传因素在Ⅱ型糖尿病发病中占有重要地位 |
| English Abstract: |
| Objective To study the relationship between genetic factors and the development of NIDDM. Methods A case-control study including 350 pedigrees (184 cases and 166 controls) was carried out to explore the etiology of family aggregation of NIDDM in Changzhou city,March 1997. Results The total prevalence rate of the first-degree relatives was 3.47%, significantly higher than 1.03% in controls (χ 2= 17.66, P 0.01). The similar results were also found in their parents, siblings and younger generation. Results Results from binominal distribution analysis showed that the number of cases in the families of NIDDM was significantly bigger than the theoretical range, indicating that there was significant familial aggregationin in the occurance of NIDDM. Simple and multiple logistic regression analysis also showed that genetic factor was one of the most important factors in the development of NIDDM. Conclusion Genetic factor was an important factor in the occurance of NIDDM. |
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