| 汪华,还锡萍,强福林,熊海平,王彩生,陈杰,陈智高,李德庆,李兰玉.布鲁氏菌属内S型和R型菌种在动物体内干扰的研究[J].Chinese journal of Epidemiology,1999,20(6):364-367 |
| 布鲁氏菌属内S型和R型菌种在动物体内干扰的研究 |
| A study on the interference between smooth and rough species of Brucella in mice and dogs |
| Received:August 11, 1999 Revised:October 11, 1999 |
| DOI： |
| KeyWord: 布鲁氏菌 抗原干扰 |
| English Key Word: Brucella Interference of antigens |
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| Abstract: |
| 目的 通过对布鲁氏菌属内Ｓ型与Ｒ 型菌种在小鼠和犬体内相互作用的研究，弄清我国布病防治中某些流行病学现象的机理。方法 将特定浓度的Ｓ型菌悬液分别与Ｒ 型菌液混合后注射于小白鼠和犬体内，２０ ～２５ 天后解剖取小鼠局部淋巴结、肝、脾及犬脾进行培养、分离及鉴定。结果 在小鼠试验中，各种Ｓ型布氏菌均明显地干扰了Ｒ 型犬种菌的生存。但在犬体内进行的研究表明，１０４Ｍ 菌被ＲＭ６／６６ 菌干扰；Ｒｅｖ － １ 菌与ＲＭ６／６６ 菌则或相互干扰，或相互平衡。Ｓ２ 在与ＲＭ６／６６ 相同菌量情况下，两者可以共存，以Ｓ２ 稍占优势，呈互不干扰、相互共处之态。结论 研究结果能合理解释Ｓ型布病疫区内很难分离到Ｒ 型布氏菌的流行病学现象，并阐明其流行病学意义。同时提示人们，当某地布病流行的优势菌被控制后，很可能出现新的优势种的布氏菌传播、流行 |
| English Abstract: |
| Objective To find out the epidemiological phenomenon in the process of brucellosis control, a study was carried out. Methods Smooth- B.abortus 104M, B.melitensis Rev-1 and B.suis mixed with Rough- B.canis RM6/66 were injected to mice and dogs respectively. After 20-25 days the spleen, liver, lymphonodus of these animals were cultivated for culture and identification of bacteria. Results In mice, smooth Brucelleae interfered the growth of the rough ones. But in dogs, the situation was different: 104M was disturbed by RM6/66, Rev-1 and RM6/66 played even while S 2 co- existing with RM6/66. Conclusion For the first time this study rationally explained the reason why rough Brucelleae could not be isolated in epidemic focus of brucellosis with smooth species. It also pointed out that when dominate species were controlled in epidemic focus areas, there might occur new transmission and prevalence of new species of Brucelleae. |
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