甲型肝炎减毒活疫苗加强免疫效果的初步研究

汪萱怡; 马景臣; 张勇; 张英林; 韩常全; 邢占春; 陈吉朝; 张玉伟; 赵守军; 顾惠心; 徐志一

Abstract

汪萱怡,马景臣,张勇,张英林,韩常全,邢占春,陈吉朝,张玉伟,赵守军,顾惠心,徐志一.甲型肝炎减毒活疫苗加强免疫效果的初步研究[J].Chinese journal of Epidemiology,2000,21(2):124-127

甲型肝炎减毒活疫苗加强免疫效果的初步研究

Primary study on immunologic effect of live attenuated hepatitis A vaccine (H2 strain)after booster dose

Received:October 21, 1999

DOI：

KeyWord: 甲型肝炎减毒活疫苗加强免疫免疫原性

English Key Word: Hepatitis A Live attenuated vaccine Booster Immunogenicity

FundProject:“ 九五” 国家医学科技攻关项目(96-906-03-01)

Author Name	Affiliation
WANG Xuanyi	Shanghai Medical University, Shanghai 200032, China
MA Jingchen	河北省正定县卫生防疫站
ZHANG Yong	河北医科大学流行病学教研室
张英林	河北省正定县卫生防疫站
韩常全	河北省正定县卫生防疫站
邢占春	河北省正定县卫生防疫站
陈吉朝	河北省正定县卫生防疫站
张玉伟	河北省正定县卫生防疫站
赵守军	Shanghai Medical University, Shanghai 200032, China
顾惠心	Shanghai Medical University, Shanghai 200032, China
徐志一	Shanghai Medical University, Shanghai 200032, China

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Abstract:

目的　观察甲型肝炎 (甲肝 )减毒活疫菌 (10 7. 0 TCID50 )加强免疫效果, 并同活疫苗一针法结果进行比较. 方法　在河北省正定县选择 42名经事先检测甲肝抗体阴性的易感儿童, 分别于0、2和 6个月各接种一剂甲肝减毒活疫苗, 并于接种后 1、2、6、7、9和 12个月采集血清标本, 观察免后抗体动态变化. 结果　第 1剂接种后 1个月抗体阳转率达 81. 4%, 第 2剂免后抗体阳转率达 10 0 %, 抗体水平于第 3剂免后 1个月达高峰, 为 2 739mIU/ml, 以后呈下降趋势, 免后 12个月抗体阳转率仍为 10 0 %, 抗体水平下降至 979mIU/ml. 结论　甲型肝炎减毒活疫苗加强免疫能诱导良好的免疫回忆反应, 其免疫学效果同史克灭活疫苗相当, 而明显高于活疫苗一针法. 活疫苗加强免疫中, 初免是基础. 活疫苗加强免疫会提高疫苗保护效果, 并延长疫苗的免疫持久性

English Abstract:

Objective To study the immunologic effect of live attenuated hepatitis A vaccine (H₂ Strain, 10^{7. 0}TCID₅₀)after booster and to compare with the Results of 1 dose live attenuated hepatitis A vaccine (H₂ Strain, 10^{7. 0}TCID₅₀). Methods 42 susceptibles with negative anti-HAV were selected in Zheng ding, Hebei province. Each subject received 3 do ses live attenuated hepatitis A vaccine at 0, 2, 6 months and was bled at 1, 2, 6, 7, 9, 12 months after vaccination. Results The seroconversion rate at 1 month after the first dose was 81. 4% and reached 100% after the second dose. GMT arrived the peak 2 739mIU/ml at one month after the third dose, before stared declining. The seroconversion rate kept 100% at 12 months after the first dose, but GMT decreased to 979 mIU/ml. Conclusion　The first dose worked as the base of boostering. A booster dose of live attenuated hepatitis A vaccine could induce secondary immune response well. The immunologic effect after booster dose could match the effect with inactivated vaccine and was better than the Results of 1 dose live attenuated hepatitis A vaccine. The program seemed to be useful to the protective effect and the immuno-persistence.

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