| 王涛,胡永华,李立明,詹思延,高原原,曹卫华,吴涛,李晓晖,郭晓霞.亚甲基四氢叶酸还原酶基因和血压水平的遗传流行病学研究-同胞对连锁分析[J].Chinese journal of Epidemiology,2000,21(3):198-201 |
| 亚甲基四氢叶酸还原酶基因和血压水平的遗传流行病学研究-同胞对连锁分析 |
| An genetic epidemiology study of MTHFR gene and blood level（sibpair linkage analysis) |
| Received:February 01, 2000 |
| DOI： |
| KeyWord: 血压水平 基因,5,10亚甲基四氢叶酸还原酶 同胞对连锁分析 |
| English Key Word: Blood pressure level MTHFR gene Sibpair linkage analysis |
| FundProject:国家“九五”攻关课题（编号：96-906-02-05） |
| Author Name | Affiliation | | WANG Tao | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | HU Yonghua | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | LI Liming | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 詹思延 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 高原原 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 曹卫华 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 吴涛 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 李晓晖 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China | | 郭晓霞 | Department of Epidemiology, Beijing Medical University, Beijing 100083, China |
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| Abstract: |
| 目的 探索 5，10 亚甲基四氢叶酸还原酶（MTHFR）基因与血压水平的连锁关系。方法 研究现场选择在原发性高血压社区综合防治项目农村社区-北京市房山区良各庄村和黄山店村。研究对象为该现场的 142对同胞对，及可能获得的父母。基因型测量包括血凝块中提取DNA，PCR扩增目的基因片断，酶切分析MTHFR基因多态性。表型为血压水平，协变量的测量包括问卷调查、体格指标及血液生化指标的测量。统计分析方法为数量型同胞对连锁分析，分析软件为SAGE。结果 在研究人群MTHFR基因 677位C和T等位基因频率分别为0.70和0.30，基因型频率（CC、CT、TT）分别为 49.7%、41.0%和 9.3%。没有发现MTHFR基因与血压水平存在连锁（P>0.0 5）。结论 本研究人群MTHFR基因不太可能是决定血压水平的主基因。 |
| English Abstract: |
| Objective To explore the relationship between MTHFR g ene and blood pressure. Methods A to tal of 142 sibpairs were collected from rural communities of CCPACH.MTHFR geneg enotypes were determined by an assay based on the polymerase chain reaction.Phenotype of this study w as the level of blood pressure.Covariates were measured by questionnare, physical ex amination and clinical indices.Sibpair linkage analy sis w as used to analy se data by SAGE software.Results I n this study, prevalence of T T genotype of MTHFR g ene was 9.3%, while CT w as 41%.There w as no evidence fo r linkage of the MTHFR gene with either systolic or diastolic blood pressure identified.Conclusion In our study population, MTHFR gene did not seem to be not related to bloo d pressure. |
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