| 单江,施育平,傅国胜.血管紧张素转换酶基因多态性与冠心病危险因素的关系[J].Chinese journal of Epidemiology,2000,21(3):208-211 |
| 血管紧张素转换酶基因多态性与冠心病危险因素的关系 |
| The relationship between angiotensin converting enzyme gene polymorphismand risk factors for coronary heart disease |
| Received:February 26, 2000 |
| DOI： |
| KeyWord: 冠心病 血管紧张素转换酶 基因 危险因素 |
| English Key Word: Co ronary heart disease Angio tensin converting enzyne Genes Risk factors |
| FundProject:浙江省医药卫生科研基金资助（编号：96215） |
| Author Name | Affiliation | | SHAN Jiang | Department of Cardiology, 2nd Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China | | SHI Yuping | Department of Cardiology, 2nd Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China | | FU Guosheng | Department of Cardiology, 2nd Affilliated Hospital, Medical College, Zhejiang University, Hangzhou 310009, China |
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| Abstract: |
| 目的 探讨血管紧张素转换酶（ACE）基因多态性与冠心病危险因素的关系。方法 应用聚合酶链反应技术和遗传学方法，测定 15 9名汉族正常人、148例冠心病患者的ACE基因插入/缺失（I/D）多态性频率，并调查冠心病患者经典危险因素。结果 ①ACE基因型分布与冠心病患者的年龄、性别、体重指数（BMI）、收缩压、舒张压、总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）、HDL2 、HDL3 、载脂蛋白（Apo）AI、ApoB、脂蛋白〔Lp（a）〕以及高血压病（HT）、吸烟、糖尿病（DM）和肥胖间差异均无显著性（P均>0.0 5）；②以ApoB<12 5mg/dl和BMI≤2 4kg/m2；或TC<2 30mg/dl、TG<2 0 0mg/dl、LDL<16 0mg/dl和BMI≤ 2 4kg/m2；及不合并HT和DM者定义为冠心病低危险亚组，分别与正常人比较，DD基因型频率（构成比）分别为 0.2 5 7、0.315和0.2 73，均显著高于正常人（χ2 =3.98、7.80、4.0 1，P均<0.0 5）。结论 ACE基因多态性与冠心病经典危险因素无关，DD基因型可能是中国人冠心病的一个独立危险因素。 |
| English Abstract: |
| Objective To ex plore the relationship between ang iotensin co nverting enzyme(ACE) gene polymo rphism and risk facto rs for coro nary heart disease(CHD).Methods 148 patients with CHD and 159 unrelated healthy individuals were studied using polymorase chain reaction（PCR) and genetic Methods.Risk factors of CHD were assessed by standard questionnaire, physical examination and bloodtests.Results ①There were no significant differences amo ng geno ty pes in terms of years, sex, body mass index(BMI), sy stolic blood pressure, diastolic blood pressure, total cholesterol(TC), trig lyceride(TG), low-density lipoprotein-cho lesterol（LDL), high-density lipoprotein-cholesterol（HDL), HDL2, HDL3, apolipoprotein(Apo)AI, ApoB, and lipo protein（a)〔Lp（a)〕.The prevalence rates of hy perlipidemia, hypertension(HT), cigarette smoking, diabetes mellitus(DM) and obesity were similar in the ACE g enotypes（P >0.05).② The DD genotype frequencies in low CHD risk groups, as defined by ApoB< 125 mg/dl and BMI ≤24 kg/m2, or TC<230 mg/dl, TG<200 mg/dl, LDL<160 mg/dl and BMI ≤24 kg/m2 w ithout HT and DM w ere significantly hig her than that in normal subjects（0.257, 0.315, 0.273 vs 0.157,χ2=3.98、7.80 、4.01, P<0.05).Conclusion There was no correlations between ACE g ene polymorphism and the classic CHD risk factors noticed.ACE DD genotype seemed to be an independent risk factor for CHD in the Chinese population. |
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