| 王启俊,李玲,祝伟星,邢秀梅,周燕荣.中国城市居民乳腺癌危险因素的研究[J].Chinese journal of Epidemiology,2000,21(3):216-220 |
| 中国城市居民乳腺癌危险因素的研究 |
| Study on risk factors of breast cancer among urban women in China |
| Received:March 03, 2000 |
| DOI： |
| KeyWord: 乳腺肿瘤 病例对照研究 聚类分析 |
| English Key Word: Breast cancer Case-control study Cluster analysis |
| FundProject:国家“九五”攻关课题（编号：96-906-01-01） |
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| Abstract: |
| 目的 乳腺癌是全世界妇女中最多发的肿瘤。我国城市女性乳腺癌危险因素的筛查及其探索监测方法研究（并有相关的论文陆续发表），对乳腺癌的预防和控制十分重要。方法 在我国选择北京、天津、上海、重庆、武汉、广州六大城市作为监测地区，采用以人群为基础的 1：1配对的病例对照研究方法，共抽取 2 10 0对病例与对照，进行问卷调查。应用SAS 6.12软件进行单因素、多因素条件logistic回归分析，并对六城市分别做指标聚类分析和样品聚类分析。结结果 六城市资料分别分析的结果为：文化程度高（OR：1.2 0~1.6 1）、体重指数大（OR：1.40~2 2.36）、精神心理压抑（OR：16.0~10.5 0）、女性生殖系统疾病史（OR：1.73~19.44）、摄入乳类食品多（OR：1.6 4~3.39）等为六城市共同的主要危险因素；而初潮年龄早、结婚年龄晚、行经年龄多、饮食中肉类、蛋类、鱼虾类摄入量高等危险因素在不同城市中出现；常吃葱蒜类食物及避孕年数多为保护性因子，绝经前与绝经后的危险因素及效应强度均有所不同；聚类分析显示北京、武汉、重庆为一类，上海、天津相类似，而广州为单独一类。结论 我国六城市妇女乳腺癌危险因素中有共同的暴露因素，同时，在不同城市之间的主要危险因素及暴露水平又有一定差异。 |
| English Abstract: |
| Obective Breast cancer is the most commo n malig nant neoplasm in women all over the w orld.It is necessary to establish monitoring Methods and to identify risk factors.Methods Six cities including Beijing, Shang hai, Tianjin, Chongqing, Wuhan and Guang zhou were chosen as the sample areas. 2 100 cases w ith 1∶1 matched co ntrols were interview ed with a uniformed questionnaire.Conditional logistic reg ression and cluster analy sis were used for multiv ariate analysis.Results The common risk factors for the combined data of the six cities w ere hig h educational level（OR:1.17), high body mass index（OR:1.51), high intake of milk products（OR:1.49), high intake of eggs（OR:1.14), psycho logical depression（OR:2.78), history of benign breast diseases（OR:2.24), old age at mar riage (OR:1.42), dy smenor rhea（OR:1.22), sho rt duration of lactation（OR:1.17).Among these factors, different cities had different ORs, as hig h educational level（OR:1.20-1.61), high body mass index (OR:1.40-22.36), high intake of milk products（OR:1.64-3.39), depression（OR:1.60-10.50), histo ry of benign breast diseases（OR:1.73-19.44).Some statistically sig nificant co rrelations existed in different cities such as early age at menarche, old age at marriage, long menstrual periods, hig h intake of meat, eggs, sea food and passive smoking w ere risk factors.Some risk facto rs varied betw een premenopausal and postmenopausal women.Beijing, Wuhan and Chong qing were clustered as the same group in cluster analysis, so did Shang hai and Tianjin, but Guang zhou could not be grouped with other cities.Conclusion Some common risk factors fo r breast cancer did ex ist in the six cities, but there were varieties in different areas which show ed different places would have their ow n characteristics.Thus, careful study of risk factors, especially in the selection of variables and data analysis need to be carried on. |
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