| 黄贵彪,万宗举,李荣成.巴维信甲型肝炎灭活疫苗在儿童与成人中应用的安全性和免疫原性研究[J].Chinese journal of Epidemiology,2000,21(4):287-288 |
| 巴维信甲型肝炎灭活疫苗在儿童与成人中应用的安全性和免疫原性研究 |
| The investigation on the safety and immunogenicity of inactived hepatitis A vaccine AVAXIM |
| Received:April 21, 2000 |
| DOI： |
| KeyWord: 甲型肝炎 疫苗接种 免疫原性 |
| English Key Word: Hepatitis A Vaccination Immuogenicity |
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| Abstract: |
| 目的 了解巴维信甲型肝炎灭活疫苗(AVAXIM)在儿童与成人中应用的安全性和免疫原性。方法 选抗-HAV阴性的121名6～12岁儿童和108名18岁以上成人，采用0、6月免疫程序接种AVAXIM(0.5 ml,160抗原单位）。结果 儿童组与成人组首针免后1个月抗-HAV IgG阳转率分别为98.15％和94.17％；第二针免后1个月分别为100.00％和97.22％，儿童组抗体阳转率略高于成人组，但无统计学意义（P＞0.05）。AVAXIM接种反应轻微，主要为局部疼痛，两组每次接种后的发生率在1.7％～2.8％之间；全身反应为发热，两组每次接种后的发生率在0.9％～2.5％之间，未见严重的全身反应和局部反应。结论 AVAXIM具有良好的安全性和免疫原性，不仅适用于成人，同样可用于儿童的免疫接种。 |
| English Abstract: |
| Objectives To investigate the safety and immunogenicity of AVAXIM in children and adults. Methods One hundred and twenty-one children aged 6-12 years and 108 adults with negative HAV antibody,were inoculated by 0,6 month procedure with inactived HAV vaccine produced by Pasteur Merieux Connaught (AVAXIM 160 antigen unit). Results The positive rates of anti-HAV IgG among children group and adult group were 98.15% and 94.17% respectively after one month of first inoculation, and became 100% and 97.22% after one month of second inoculation. The antibody positive rate was higher in children than in adults, but did not show statistical significance (P＜0.05). The side effects of AVAXIM inoculation were mild, mainly local pain with occurrences 1.7%-2.8% in both groups. No serious systemic and local reactions were noticed. Conclusion AVAXIM had good safety and immunogenicity, seen not only in adults, but also in children. |
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